Evidence map›Paper›PMID 34499026›Full record

ArticleMicrobial genomics2021

Gene-gene relationships in an

Rebecca J Hall, Fiona J Whelan, Elizabeth A Cummins, Christopher Connor, Alan McNally, James O McInerney

Open access · goldAbstract read
In one paragraph

Article in Microbial genomics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
3.6field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed, 37 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
  4. Cooperation and the evolution of bacterial niche breadth.Proceedings of the National Academy of Sciences of the United States of America · 2026
    Article
  5. Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. A phylogenetic approach to comparative genomics.Nature reviews. Genetics · 2025
    Review
  13. Article
  14. Review
  15. Genomic insights into extended-spectrumJournal of medical microbiology · 2025
    Article
  16. Article
  17. Genomic analysis of multidrug-resistantFrontiers in microbiology · 2025
    Article
  18. Review
  19. Article
  20. Bacterial lifestyle shapes pangenomes.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Rebecca J HallInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Fiona J WhelanSchool of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.
Elizabeth A CumminsInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Christopher ConnorInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
Alan McNallyInstitute of Microbiology and Infection, College of Medical and Dental Sciences, University of Birmingham, Birmingham, B15 2TT, UK.
James O McInerneySchool of Life Sciences, University of Nottingham, Nottingham, NG7 2UH, UK.
University of Nottingham · GBUniversity of Birmingham · GB

Funding

Biotechnology and Biological Sciences Research Council BB/N018044/2Wellcome Trust
6 · The paper itself

Abstract

The pangenome contains all genes encoded by a species, with the core genome present in all strains and the accessory genome in only a subset. Coincident gene relationships are expected within the accessory genome, where the presence or absence of one gene is influenced by the presence or absence of another. Here, we analysed the accessory genome of an

Indexed as

Genome, BacterialDNA Transposable ElementsEscherichia coliEscherichia coli InfectionsEvolution, MolecularGenes, BacterialPhylogenyVirulenceDNA Transposable ElementsEscherichia colievolutiongene co-occurrencepangenome

Identifiers

PMID34499026
PMCPMC8715431
OpenAlexW3196982248

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.