Evidence map›Paper›PMID 34498948›Full record

ArticleAIDS research and human retroviruses2022

Metabolomics in Placental Tissue from Women Living with HIV.

Huda B Al-Kouatly, Rachel K Scott, Mona M Makhamreh, Gary Cunningham, Timothy Visclosky, Brian O Ingram, Kengo Inagaki, Natella Rakhmanina, Brian Kirmse

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in AIDS research and human retroviruses, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact, top 86% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 1 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 1 country.

Huda B Al-KouatlyDivision of Maternal-Fetal Medicine, Department of Obstetrics and Gynecology, MedStar Washington Hospital Center, Washington, District of Columbia, USA.ORCID 0000-0003-2922-0333
Rachel K ScottMedStar Health Research Institute, Washington, District of Columbia, USA.
Mona M MakhamrehDepartment of Obstetrics and Gynecology, Maimonides Medical Center, Brooklyn, New York, USA.
Gary CunninghamDivision of Genetics & Metabolism, Children's National Hospital, Washington, District of Columbia, USA.
Timothy ViscloskyDepartment of Emergency Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Brian O IngramMetabolon, Inc., Raleigh, North Carolina, USA.
Kengo InagakiDivision of Pediatric Infectious Diseases, Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.
Natella RakhmaninaDivision of Infectious Diseases, Children's National Hospital, Washington, District of Columbia, USA.
Brian KirmseDivision of Medical Genetics, Department of Pediatrics, University of Mississippi Medical Center, Jackson, Mississippi, USA.ORCID 0000-0002-9350-5029
MedStar Washington Hospital Center · USUniversity of Mississippi Medical Center · USChildren's National · USElizabeth Glaser Pediatric AIDS Foundation · USMaimonides Medical Center · USMetabolon (United States) · USUniversity of Michigan · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

It is unknown whether antiretroviral (ARV) drugs in women living with HIV (WLHIV) are associated with mitochondrial toxicity and altered fat oxidation and branched-chain amino acid metabolism in the placenta and fetus. Immediately after delivery, we froze placental biopsies from 20 WLHIV and 20 matched uninfected women. We analyzed global biochemical profiles using high-performance liquid chromatography/tandem mass spectrometry and gas chromatography/mass spectrometry. We used

Indexed as

Anti-HIV AgentsHIV InfectionsAnti-Retroviral AgentsFemaleHumansInfant, NewbornMetabolomicsPlacentaPregnancyAnti-HIV AgentsAnti-Retroviral Agentsacylcarnitineamino acidsantiretroviral therapyHIVmetabolismplacenta

Identifiers

PMID34498948
PMCPMC8968831
OpenAlexW3197126695

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.