ArticleCerebral cortex (New York, N.Y. : 1991)2022
Functional Connectivity of the Developing Mouse Cortex.
Article in Cerebral cortex (New York, N.Y. : 1991), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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Who cites it
16 citing papers in PubMed, 24 citations in OpenAlex.
- PSD-95 drives binocular vision maturation critical for predation.bioRxiv : the preprint server for biology · 2026Article
- State-Dependent Organization of Microscale Functional Circuitry in Visual Cortex.bioRxiv : the preprint server for biology · 2026Article
- Correspondence of large-scale functional brain network decline across aging mice and humans.Proceedings of the National Academy of Sciences of the United States of America · 2026Article
- The histone methyltransferase SETD2 regulates adult brain structure, connectivity and neurogenesis.Scientific reports · 2025Article
- Age-dependent cortical overconnectivity in Shank3 mice is reversed by anesthesia.Translational psychiatry · 2025Article
- Zika virus encephalitis causes transient reduction of functional cortical connectivity.Neurophotonics · 2025Article
- Intact-skull cranial windows for widefield optical imaging in juvenile mice: complications and consequences.Journal of the Optical Society of America. A, Optics, image science, and vision · 2024Article
- Visual Deprivation during Mouse Critical Period Reorganizes Network-Level Functional Connectivity.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2024Article
- Mapping brain function in adults and young children during naturalistic viewing with high-density diffuse optical tomography.Human brain mapping · 2024Article
- Global spatiotemporal synchronizing structures of spontaneous neural activities in different cell types.Nature communications · 2024Article
- Spatial nonstationarity of image noise in widefield optical imaging and its effects on cluster-based inference for resting-state functional connectivity.Journal of neuroscience methods · 2024Article
- Mecp2 deletion results in profound alterations of developmental and adult functional connectivity.Cerebral cortex (New York, N.Y. : 1991) · 2023Article
- Controlling the familywise error rate in widefield optical neuroimaging of functional connectivity in mice.Neurophotonics · 2023Article
- Open-source statistical and data processing tools for wide-field optical imaging data in mice.Neurophotonics · 2023Article
- Statistical approaches to temporal and spatial autocorrelation in resting-state functional connectivity in mice measured with optical intrinsic signal imaging.Neurophotonics · 2022Article
- Concurrent optogenetic motor mapping of multiple limbs in awake mice reveals cortical organization of coordinated movements.Brain stimulationArticle
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
Abstract
Cross-sectional studies have established a variety of structural, synaptic, and cell physiological changes corresponding to critical periods in cortical development. However, the emergence of functional connectivity (FC) in development has not been fully characterized, and hemodynamic-based measures are vulnerable to any neurovascular coupling changes occurring in parallel. We therefore used optical fluorescence imaging to trace longitudinal calcium FC in the awake, resting-state mouse cortex at 5 developmental timepoints beginning at postnatal day 15 (P15) and ending in early adulthood at P60. Calcium FC displayed coherent functional maps as early as P15, and FC significantly varied in connections between many regions across development, with the developmental trajectory's shape specific to the functional region. Evaluating 325 seed-seed connections, we found that there was a significant increase in FC between P15 and P22 over the majority of the cortex as well as bilateral connectivity and node degree differences in frontal, motor, and retrosplenial cortices after P22. A rebalancing of inter- and intrahemispheric FC and local-distal FC dominance was also observed during development. This longitudinal developmental calcium FC study therefore provides a resource dataset to the field and identifies periods of dynamic change which cross-sectional studies may target for examination of disease states.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.