ArticleBrain and behavior2021
Structural disconnectivity from paramagnetic rim lesions is related to disability in multiple sclerosis.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. An erratum has been issued. Cited by 18 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
18 citing papers in PubMed, 29 citations in OpenAlex.
- Depression as a Disease of White Matter Network Disruption: Learning From Multiple Sclerosis.Biological psychiatry · 2026Review
- Smoldering neuroinflammation in progressive multiple sclerosis: mechanisms, imaging biomarkers, and therapeutic opportunities.Frontiers in immunology · 2026Review
- Neurodegeneration correlates of iron-related lesions and leptomeningeal inflammation in multiple sclerosis clinical subtypes.Neuroradiology · 2025Article
- Impact of paramagnetic rim lesions on disability and race in multiple sclerosis: mediation analysis.Annals of clinical and translational neurology · 2024Observational
- Imaging chronic active lesions in multiple sclerosis: a consensus statement.Brain : a journal of neurology · 2024Review
- Structural and functional imaging features of cognitive phenotypes in pediatric multiple sclerosis.Annals of clinical and translational neurology · 2024Article
- Mapping the Relationship of White Matter Lesions to Depression in Multiple Sclerosis.Biological psychiatry · 2024Article
- Mapping the relationship of white matter lesions to depression in multiple sclerosis.medRxiv : the preprint server for health sciences · 2023Article
- An Interpretable Machine Learning Model to Predict Cortical Atrophy in Multiple Sclerosis.Brain sciences · 2023Article
- An investigation of the association between focal damage and global network properties in cognitively impaired and cognitively preserved patients with multiple sclerosis.Frontiers in neuroscience · 2023Article
- The sequence of regional structural disconnectivity due to multiple sclerosis lesions.Brain communications · 2023Article
- Dimethyl Fumarate Reduces Inflammation in Chronic Active Multiple Sclerosis Lesions.Neurology(R) neuroimmunology & neuroinflammation · 2022Observational
- Corrigendum.Brain and behavior · 2022Article
- Structural disconnectivity from paramagnetic rim lesions is related to disability in multiple sclerosis.Brain and behavior · 2021Article
- Estimated connectivity networks outperform observed connectivity networks when classifying people with multiple sclerosis into disability groups.NeuroImage. Clinical · 2021Article
- Dynamic Functional Connectivity Better Predicts Disability Than Structural and Static Functional Connectivity in People With Multiple Sclerosis.Frontiers in neuroscience · 2021Article
- TSPO-PET reveals higher inflammation in white matter disrupted by paramagnetic rim lesions in multiple sclerosis.Imaging neuroscience (Cambridge, Mass.)Article
- Prediction of high and low disease activity in early MS patients using multiple kernel learning identifies importance of lateral ventricle intensity.Multiple sclerosis journal - experimental, translational and clinicalArticle
Corrections and comments
- Erratum issuedCorrigendum.2022
Authors and funding
9 authors at 1 institution in 1 country.
Funding
Abstract
backgroundIn people with multiple sclerosis (pwMS), lesions with a hyperintense rim (rim+) on Quantitative Susceptibility Mapping (QSM) have been shown to have greater myelin damage compared to rim- lesions, but their association with disability has not yet been investigated. Furthermore, how QSM rim+ and rim- lesions differentially impact disability through their disruptions to structural connectivity has not been explored. We test the hypothesis that structural disconnectivity due to rim+ lesions is more predictive of disability compared to structural disconnectivity due to rim- lesions.
methodsNinety-six pwMS were included in our study. Individuals with Expanded Disability Status Scale (EDSS) <2 were considered to have lower disability (n = 59). For each gray matter region, a Change in Connectivity (ChaCo) score, that is, the percent of connecting streamlines also passing through a rim- or rim+ lesion, was computed. Adaptive Boosting was used to classify the pwMS into lower versus greater disability groups based on ChaCo scores from rim+ and rim- lesions. Classification performance was assessed using the area under ROC curve (AUC).
resultsThe model based on ChaCo from rim+ lesions outperformed the model based on ChaCo from rim- lesions (AUC = 0.67 vs 0.63, p-value < .05). The left thalamus and left cerebellum were the most important regions in classifying pwMS into disability categories.
conclusionrim+ lesions may be more influential on disability through their disruptions to the structural connectome than rim- lesions. This study provides a deeper understanding of how rim+ lesion location/size and resulting disruption to the structural connectome can contribute to MS-related disability.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.