Evidence map›Paper›PMID 34498352›Full record

Trial reportThe oncologist2022

Effects of a 12-Week Multimodal Exercise Intervention Among Older Patients with Advanced Cancer: Results from a Randomized Controlled Trial.

Marta K Mikkelsen, Cecilia M Lund, Anders Vinther, Anders Tolver, Julia S Johansen, Inna Chen, Anne-Mette Ragle, Bo Zerahn, Lotte Engell-Noerregaard, Finn O Larsen and 3 more

Registry-linked trialOpen access · bronzeAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in The oncologist, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05915325 (Physical Training for Elderly Cancer Patients With Cachexia), which is not on this map. Cited by 57 papers, 9 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
57citing papers in PubMed, 9 pooled it
5.5field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05915325 naactive not recruitingnot on this mapstarted 2023, after this paper: background citation

Physical Training for Elderly Cancer Patients With Cachexia (TEECH-01): a Prospective Clinical Trial

TypeinterventionalSponsorNational Cheng-Kung University HospitalRan2023 to 2026Enrolled23ConditionsGeriatric Assessment, Cancer, Cancer CachexiaArmsPhysical training
3 · Its place in the literature

Who cites it

57 citing papers in PubMed, 9 syntheses or guidelines pooled it, 107 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Pooled it
  6. Pooled it
  7. Non-pharmacological interventions targeting mobility among people with advanced cancer: a systematic review.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Pooled it
  8. Pooled it
  9. Pooled it
  10. Trial
  11. Trial
  12. P-move: a randomized control trial of exercise in patients with advanced pancreatic or biliary tract cancer (aPBC) receiving beyond first-line chemotherapy.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024
    Trial
  13. Trial
  14. Trial
  15. Trial
  16. Review
  17. Article
  18. Article
  19. Review
  20. Review
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 1 country.

Marta K MikkelsenDepartment of Oncology, Center for Cancer and Organ Diseases, Copenhagen University Hospital, Rigshospitalet, Copenhagen, Denmark.
Cecilia M LundDepartment of Medicine, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
Anders VintherDepartment of Physiotherapy and Occupational Therapy, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
Anders TolverData Science Laboratory, Department of Mathematical Sciences, University of Copenhagen, Copenhagen, Denmark.
Julia S JohansenDepartment of Oncology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
Inna ChenDepartment of Oncology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
Anne-Mette RagleDepartment of Physiotherapy and Occupational Therapy, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
Bo ZerahnDepartment of Clinical Physiology and Nuclear Medicine, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
Lotte Engell-NoerregaardDepartment of Oncology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
Finn O LarsenDepartment of Oncology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
Susann TheileDepartment of Oncology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
Dorte L NielsenDepartment of Oncology, Copenhagen University Hospital, Herlev and Gentofte Hospital, Herlev, Denmark.
Mary JardenDepartment of Clinical Medicine, Faculty of Health and Medical Sciences, Copenhagen University, Copenhagen, Denmark.
Gentofte Hospital · DKUniversity of Copenhagen · DKCopenhagen University Hospital · DK

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundOlder patients with cancer are at risk of physical decline and impaired quality of life during oncological treatment. Exercise training has the potential to reduce these challenges. The study aim was to investigate the feasibility and effect of a multimodal exercise intervention in older patients with advanced cancer (stages III/IV). PATIENTS AND

methodsEighty-four older adults (≥65 years) with advanced pancreatic, biliary tract, or non-small cell lung cancer who received systemic oncological treatment were randomized 1:1 to an intervention group or a control group. The intervention was a 12-week multimodal exercise-based program including supervised exercise twice weekly followed by a protein supplement, a home-based walking program, and nurse-led support and counseling. The primary endpoint was change in physical function (30-second chair stand test) at 13 weeks.

resultsMedian age of the participants was 72 years (interquartile range [IQR] 68-75). Median adherence to the exercise sessions was 69% (IQR 21-88) and 75% (IQR 33-100) for the walking program. At 13 weeks, there was a significant difference in change scores of 2.4 repetitions in the chair stand test, favoring the intervention group (p < .0001). Furthermore, significant beneficial effects were seen for physical endurance (6-minute walk test), hand grip strength, physical activity, symptom burden, symptoms of depression and anxiety, global health status (quality of life), and lean body mass. No effects were seen for dose intensity, hospitalizations, or survival.

conclusionA 12-week multimodal exercise intervention with targeted support proved effective in improving physical function in older patients with advanced cancer during oncological treatment.

Indexed as

Carcinoma, Non-Small-Cell LungLung NeoplasmsAgedExercise TherapyHand StrengthHumansQuality of Lifeadvanced cancerexerciseolder patientsrandomized controlled trialresistance trainingsupport

Identifiers

PMID34498352
PMCPMC8842365
OpenAlexW3197592961

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.