Evidence map›Paper›PMID 34498151›Full record

ArticleJournal of autism and developmental disorders2022

Associations Between Hyperphagia, Symptoms of Sleep Breathing Disorder, Behaviour Difficulties and Caregiver Well-Being in Prader-Willi Syndrome: A Preliminary Study.

Jessica Mackay, Gillian M Nixon, Antony R Lafferty, Geoff Ambler, Nitin Kapur, Philip B Bergman, Cara Schofield, Chris Seton, Andrew Tai, Elaine Tham and 11 more

Abstract read
PubMed Publisher
In one paragraph

Article in Journal of autism and developmental disorders, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed, 1 pooled it
0.2field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 1 synthesis or guideline pooled it, 3 citations in OpenAlex.

  1. Pooled it
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

21 authors at 10 institutions in 2 countries.

Jessica MackayTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Gillian M NixonMelbourne Children's Sleep Centre, Monash Children's Hospital, Clayton, Victoria, Australia.
Antony R LaffertyPaediatric Endocrinology and Diabetes Service, Department of Paediatrics, Canberra Hospital, Garran, Australia.
Geoff AmblerThe Sydney Children's Hospitals Network, Westmead, NSW, Australia.
Nitin KapurRespiratory and Sleep Medicine, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Philip B BergmanDepartment of Paediatrics, Monash University, Clayton, Victoria, Australia.
Cara SchofieldTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Chris SetonDepartment of Sleep Medicine, Children's Hospital Westmead, Westmead, NSW, Australia.
Andrew TaiRespiratory and Sleep Department, Women's and Children's Hospital, North Adelaide, SA, Australia.
Elaine ThamEndocrinology and Diabetes Department, Women's and Children's Hospital, North Adelaide, SA, Australia.
Komal VoraDepartment of Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, Newcastle, NSW, Australia.
Patricia CrockDepartment of Paediatric Endocrinology and Diabetes, John Hunter Children's Hospital, Newcastle, NSW, Australia.
Charles VergeDepartment of Endocrinology, Sydney Children's Hospital, Randwick, NSW, Australia.
Yassmin MusthaffaDepartment of Endocrinology and Diabetes, Queensland Children's Hospital, South Brisbane, Queensland, Australia.
Greg BlecherDepartment of Sleep Medicine, Sydney Children's Hospital, Randwick, NSW, Australia.
Daan CaudriTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Helen LeonardTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Peter JacobyTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Andrew WilsonTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Catherine S ChoongTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia.
Jenny DownsTelethon Kids Institute, The Centre for Child Health Research, The University of Western Australia, PO Box 855, West Perth, WA, 6872, Australia. Jenny.Downs@telethonkids.org.au.ORCID http://orcid.org/0000-0001-7358-9037
The Kids Research Institute Australia · AUMonash Children’s Hospital · AUThe University of Queensland · AUThe University of Sydney · AUWomen's and Children's Hospital · AUCanberra Hospital · AUHunter Medical Research Institute · AUJohn Hunter Children's Hospital · AUSydney Children's Hospital · AUUNSW Sydney · AU

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Prader-Willi syndrome (PWS) is a rare genetic disorder characterised by neurodevelopmental delays, hyperphagia, difficulties with social communication and challenging behaviours. Individuals require intensive supervision from caregivers which may negatively affect caregiver quality of life. This study used data collected in the Australasian PWS Registry (n = 50, mean age 11.2 years) to evaluate associations between child behaviours and caregiver mental well-being. Symptoms of sleep-related breathing disorder, child depression and social difficulties were associated with poorer caregiver mental and physical well-being. Growth hormone therapy use was associated with better caregiver mental and physical well-being. Optimising management of problematic behaviours and sleep disturbances have the potential to support caregivers who are the most vital network of support for individuals affected by PWS.

Indexed as

Autism Spectrum DisorderPrader-Willi SyndromeSleep Wake DisordersCaregiversChildHumansHyperphagiaQuality of LifeSleepGrowth hormoneHyperphagia; behaviourParental well-beingPrader-Willi syndromeSleep

Identifiers

PMID34498151
OpenAlexW3197033967

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.