Evidence map›Paper›PMID 34498135›Full record

Trial reportEuropean journal of applied physiology2021

Maximal strength training-induced increase in efferent neural drive is not reflected in relative protein expression of SERCA.

Tiril Tøien, Håvard Haglo, Stian Kwak Nyberg, Shalini Vasudev Rao, Astrid Kamilla Stunes, Mats Peder Mosti, Eivind Wang

Open access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in European journal of applied physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.7field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 8 citations in OpenAlex.

  1. Trial
  2. Trial
  3. Effects of electromyostimulation on sarcolipin and CaBiochemistry and biophysics reports · 2026
    Article
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  5. Article
  6. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 3 countries.

Tiril TøienDepartment of Health and Social Sciences, Molde University College, Britvegen 2, 6410, Molde, Norway. tiril.toien@himolde.no.ORCID http://orcid.org/0000-0001-9632-3848
Håvard HagloDepartment of Health and Social Sciences, Molde University College, Britvegen 2, 6410, Molde, Norway.
Stian Kwak NybergDepartment of Circulation and Medical Imaging, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Shalini Vasudev RaoCambridge Institute, University of Cambridge, Cambridge, UK.
Astrid Kamilla StunesDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Mats Peder MostiDepartment of Clinical and Molecular Medicine, Faculty of Medicine and Health Sciences, Norwegian University of Science and Technology, Trondheim, Norway.
Eivind WangDepartment of Health and Social Sciences, Molde University College, Britvegen 2, 6410, Molde, Norway.
Norwegian University of Science and Technology · NOMolde University College · NO

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMaximal strength training (MST), performed with heavy loads (~ 90% of one repetition maximum; 1RM) and few repetitions, yields large improvements in efferent neural drive, skeletal muscle force production, and skeletal muscle efficiency. However, it is elusive whether neural adaptations following such high intensity strength training may be accompanied by alterations in energy-demanding muscular factors.

methodsSixteen healthy young males (24 ± 4 years) were randomized to MST 3 times per week for 8 weeks (n = 8), or a control group (CG; n = 8). Measurements included 1RM and rate of force development (RFD), and evoked potentials recordings (V-wave and H-reflex normalized to M-wave (M) in the soleus muscle) applied to assess efferent neural drive to maximally contracting skeletal muscle. Biopsies were obtained from vastus lateralis and analyzed by western blots and real-time PCR to investigate the relative protein expression and mRNA expression of Sarcoplasmic Reticulum Ca

resultsSignificant improvements in 1RM (17 ± 9%; p < 0.001) and early (0-100 ms), late (0-200 ms) and maximal RFD (31-53%; p < 0.01) were observed after MST, accompanied by increased maximal V

conclusionMST increased efferent neural drive to maximally contracting skeletal muscle, causing improved force production. No change was observed in SERCA expression, indicating that responses to high intensity strength training may predominantly be governed by neural adaptations.

Indexed as

Adaptation, PhysiologicalResistance TrainingBiomarkersEvoked Potentials, MotorHumansMaleMuscle ContractionMuscle, SkeletalSarcoplasmic Reticulum Calcium-Transporting ATPasesYoung AdultATP2A1 protein, humanATP2A2 protein, humanBiomarkersSarcoplasmic Reticulum Calcium-Transporting ATPasesEfferent neural driveNeural adaptationsSERCAStrength training

Identifiers

PMID34498135
PMCPMC8571128
OpenAlexW3198273195

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.