Evidence map›Paper›PMID 34498107›Full record

ArticleNeuroradiology2022

Structural and functional brain changes in X-linked Charcot-Marie-Tooth disease: insights from a multimodal neuroimaging study.

Efstratios Karavasilis, Foteini Christidi, Eirini Pantou, Georgia Angelopoulou, Dimitrios Kasselimis, Marianthi Breza, Zoi Kontogeorgiou, Dimitrios Filippiadis, Constantin Potagas, Georgia Karadima and 2 more

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Article in Neuroradiology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

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2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed, 1 citations in OpenAlex.

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4 · The record

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5 · Who and what money

Authors and funding

12 authors at 1 institution in 1 country.

Efstratios Karavasilis2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece. stratoskaravasilis@yahoo.gr.ORCID http://orcid.org/0000-0002-7291-2231
Foteini ChristidiLaboratory of Medical Physics, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Eirini Pantou2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Georgia Angelopoulou1st Department of Neurology, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios Kasselimis1st Department of Neurology, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Marianthi Breza1st Department of Neurology, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Zoi KontogeorgiouNeurogenetics Unit, 1st Department of Neurology, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Dimitrios Filippiadis2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
Constantin Potagas1st Department of Neurology, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Georgia KaradimaNeurogenetics Unit, 1st Department of Neurology, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Georgios Koutsis *Neurogenetics Unit, 1st Department of Neurology, School of Medicine, Eginition Hospital, National and Kapodistrian University of Athens, Athens, Greece.
Georgios Velonakis *2nd Department of Radiology, Medical School, National and Kapodistrian University of Athens, Athens, Greece.
National and Kapodistrian University of Athens · GR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeBrain involvement in X-linked Charcot-Marie-Tooth disease (CMTX) has been previously reported. We studied the brain structural and functional integrity using a multimodal neuroimaging approach in patients with no current central nervous system (CNS) symptoms, in order to further delineate the disease's phenotype.

methodsSeventeen CMTX patients with no current CNS symptoms and 24 matched healthy controls underwent brain magnetic resonance imaging (MRI). Structural integrity was evaluated performing Gray matter analysis with voxel-based morphometry (VBM) and tract-based spatial statistics (TBSS) of diffusion tensor imaging (DTI). Functional integrity was evaluated with resting-state functional MRI (rs-fMRI).

resultsDecreased gray matter density was detected in CMTX patients compared to healthy controls in bilateral hippocampus, left thalamus, left postcentral gyrus, left superior parietal lobule, left cerebellum crus I and II, and vermis VI. DTI analysis showed increased fractional anisotropy and radial diffusivity in the right anterior insula and increased axial diffusivity in right cerebellum crus I in CMTX patients. rs-fMRI revealed decreased spontaneous neural activity on left precentral gyrus in patients compared to healthy controls.

conclusionAdvanced magnetic resonance (MR) neuroimaging techniques in CMTX patients revealed structural and functional involvement of multiple motor and extra-motor brain areas. MR neuroimaging techniques have the potential to delineate the CNS phenotype of a peripheral neuropathy like CMTX.

Indexed as

Charcot-Marie-Tooth DiseaseDiffusion Tensor ImagingBrainGray MatterHumansMagnetic Resonance ImagingNeuroimagingCharcot-Marie-ToothDiffusion tensor imagingGray matter volumetryNeuroimagingResting-state fMRI

Identifiers

PMID34498107
OpenAlexW3197204005

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.