Evidence map›Paper›PMID 34498102›Full record

ArticleAnalytical and bioanalytical chemistry2021

Multiresidue antibiotic-metabolite quantification method using ultra-performance liquid chromatography coupled with tandem mass spectrometry for environmental and public exposure estimation.

Elizabeth Holton, Barbara Kasprzyk-Hordern

Abstract read
In one paragraph

Article in Analytical and bioanalytical chemistry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Elizabeth HoltonDepartment of Chemistry, University of Bath, Bath, BA2 7AY, UK.ORCID https://orcid.org/0000-0002-6809-2875
Barbara Kasprzyk-HordernDepartment of Chemistry, University of Bath, Bath, BA2 7AY, UK. b.kasprzyk-hordern@bath.ac.uk.ORCID https://orcid.org/0000-0001-7401-4876

Funding

Engineering and Physical Sciences Research Council EP/P028403/1
6 · The paper itself

Abstract

This manuscript describes a new multiresidue method utilising ultra-performance liquid chromatography tandem mass spectrometry (UPLC-MS/MS) via multiple reaction monitoring (MRM), for the identification and quantification of 58 antibiotics and their 26 metabolites, in various solid and liquid environmental matrices. The method was designed with a 'one health' approach in mind requiring multidisciplinary and multisectoral collaborative efforts. It enables comprehensive evaluation of antibiotic usage in surveyed communities via wastewater-based epidemiology, as well as allowing for the assessment of potential environmental impacts. The instrumental performance was very good, demonstrating linearity up to 3000 μg L

Indexed as

Environmental ExposureChromatography, LiquidDrug ResiduesHumansLimit of DetectionTandem Mass SpectrometryAntibioticLiquid chromatographyMass spectrometryMetaboliteWastewater-based epidemiologyWater fingerprinting

Identifiers

PMID34498102
PMCPMC8425450

What OpenQuestion holds

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LicenceCC BY
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.