ArticleThe Plant cell2021
The versatility of plant organic acid metabolism in leaves is underpinned by mitochondrial malate-citrate exchange.
Article in The Plant cell, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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33 citing papers in PubMed, 70 citations in OpenAlex.
- Knockout of mitochondrial dicarboxylate carriers AtDIC1 and AtDIC3 affects germination, biomass accumulation, and carbon partitioning in Arabidopsis thaliana.Plant cell reports · 2026Article
- Targeting the KAT7/H3K14ac/RAC2 Axis Mediates OXPHOS to Promote Stemness Maintenance and Malignancy in Glioblastoma.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026Article
- Spatiotemporal metabolomics of tobacco leaves in response to Pseudomonas syringae infection.Plant physiology · 2026Article
- Alternative oxidase and ethylene form a positive feed-forward loop in mitochondrial retrograde signaling.Plant communications · 2026Article
- MdDIC2 contributes to salt tolerance by citric acid efflux from mitochondria to the cytoplasm in apple plants.Planta · 2026Article
- Molecular orchestration of malate and citrate metabolism: regulatory networks governing organic acid dynamics and fruit quality attributes.Horticulture research · 2026Article
- Soil-borne diseases in medicinal plants: linking allelopathy and host immunity to microbiome-based interventions.Frontiers in plant science · 2026Review
- Coordinated regulation of amino acid metabolism and transport in cereal nitrogen remobilization for grain filling.Frontiers in plant science · 2026Review
- Genome-Wide Identification and Expression Analysis of Mitochondrial Dicarboxylate Carriers (DICs) in Medicago Under Aluminum Stress.Plants (Basel, Switzerland) · 2025Article
- Malate metabolism in horticultural crops: mechanistic insights and agricultural practices for quality improvement.Molecular horticulture · 2025Review
- Article
- Roles of WRKY Transcription Factors in Response to Sri Lankan Cassava Mosaic Virus Infection in Susceptible and Tolerant Cassava Cultivars.Plants (Basel, Switzerland) · 2025Article
- Integrative analysis of transcriptome and metabolism reveals functional roles of redox homeostasis in low light and salt combined stress in Leymus chinensis.BMC genomics · 2025Article
- EARLY NODULIN93 acts via cytochrome c oxidase to alter respiratory ATP production and root growth in plants.The Plant cell · 2024Article
- Identification of key gene networks controlling organic acid and sugar metabolism during star fruit (Averrhoa carambola) development.BMC plant biology · 2024Article
- The Role of Low-Molecular-Weight Organic Acids in Metal Homeostasis in Plants.International journal of molecular sciences · 2024Review
- Mitochondrial atp1 mRNA knockdown by a custom-designed pentatricopeptide repeat protein alters ATP synthase.Plant physiology · 2024Article
- Modeling the effect of daytime duration on the biosynthesis of terpenoid precursors.Frontiers in plant science · 2024Article
- Vacuolar proteomic analysis reveals tonoplast transporters for accumulation of citric acid and sugar in citrus fruit.Horticulture research · 2024Article
- Cucumber malate decarboxylase, CsNADP-ME2, functions in the balance of carbon and amino acid metabolism in fruit.Horticulture research · 2023Article
Corrections and comments
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Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Malate and citrate underpin the characteristic flexibility of central plant metabolism by linking mitochondrial respiratory metabolism with cytosolic biosynthetic pathways. However, the identity of mitochondrial carrier proteins that influence both processes has remained elusive. Here we show by a systems approach that DICARBOXYLATE CARRIER 2 (DIC2) facilitates mitochondrial malate-citrate exchange in vivo in Arabidopsis thaliana. DIC2 knockout (dic2-1) retards growth of vegetative tissues. In vitro and in organello analyses demonstrate that DIC2 preferentially imports malate against citrate export, which is consistent with altered malate and citrate utilization in response to prolonged darkness of dic2-1 plants or a sudden shift to darkness of dic2-1 leaves. Furthermore, isotopic glucose tracing reveals a reduced flux towards citrate in dic2-1, which results in a metabolic diversion towards amino acid synthesis. These observations reveal the physiological function of DIC2 in mediating the flow of malate and citrate between the mitochondrial matrix and other cell compartments.
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