Evidence map›Paper›PMID 34498074›Full record

ArticleSleep2022

Heart rate variability as a potential biomarker of pediatric obstructive sleep apnea resolution.

Adrián Martín-Montero, Gonzalo C Gutiérrez-Tobal, Leila Kheirandish-Gozal, Fernando Vaquerizo-Villar, Daniel Álvarez, Félix Del Campo, David Gozal, Roberto Hornero

Registry-linked trialOpen access · bronzeAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT00560859 (A Randomized Controlled Study of Adenotonsillectomy for Children With Obstructive Sleep Apnea Syndrome), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.7field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT00560859 nacompletednot on this map

A Randomized Controlled Study of Adenotonsillectomy for Children With Obstructive Sleep Apnea Syndrome

TypeinterventionalSponsorUniversity of PennsylvaniaRan2007 to 2012Enrolled453ConditionsObstructive Sleep Apnea, SnoringArmsAdenotonsillectomy (AT) - removal of adenoids and tonsils, Watchful Waiting
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Adrián Martín-MonteroBiomedical Engineering Group, University of Valladolid, Valladolid, Spain.ORCID 0000-0002-8628-4563
Gonzalo C Gutiérrez-TobalBiomedical Engineering Group, University of Valladolid, Valladolid, Spain.ORCID 0000-0002-1237-3424
Leila Kheirandish-GozalDepartment of Child Health and The Child Health Research Institute, University of Missouri School of Medicine, Columbia, MO, USA.ORCID 0000-0003-3332-1057
Fernando Vaquerizo-VillarBiomedical Engineering Group, University of Valladolid, Valladolid, Spain.
Daniel ÁlvarezBiomedical Engineering Group, University of Valladolid, Valladolid, Spain.ORCID 0000-0003-1027-2395
Félix Del CampoBiomedical Engineering Group, University of Valladolid, Valladolid, Spain.
David GozalDepartment of Child Health and The Child Health Research Institute, University of Missouri School of Medicine, Columbia, MO, USA.
Roberto HorneroBiomedical Engineering Group, University of Valladolid, Valladolid, Spain.
Universidad de Valladolid · ESUniversity of Missouri Health System · US

Funding

INSTITUTIONAL CLINICAL AND TRANSLATIONAL SCIENCE AWARDUL1RR024134 · NCRR · UNIVERSITY OF PENNSYLVANIA · PI FITZGERALD, GARRET A · 2006 to 2011
$70.4M
CTSA INFRASTRUCTURE FOR PEDIATRIC RESEARCHUL1RR024989 · NCRR · CASE WESTERN RESERVE UNIVERSITY · PI DAVIS, PAMELA B · 2007 to 2011
$53.7M
Clinical and Translational Science Collaborative of ClevelandUL1TR002548 · NCATS · CASE WESTERN RESERVE UNIVERSITY · PI MCCOMSEY, GRACE A · 2018 to 2022
$35.5M
Randomized Controlled Study of Adenotonsillectomy for Childhood Sleep ApneaU01HL083075 · NHLBI · CASE WESTERN RESERVE UNIVERSITY · PI REDLINE, SUSAN S. · 2006 to 2010
$7.6M
National Sleep Research Resource (NSRR)R24HL114473 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI REDLINE, SUSAN S., ZHANG, GUO-QIANG · 2013 to 2017
$7.5M
APP-mediated signaling, sleep perturbations, and Alzheimer's disease mouse modelsRF1AG061824 · NIA · UNIVERSITY OF SOUTH FLORIDA · PI GOZAL, DAVID, PARENT, ANGELE · 2019 to 2019
$3.5M
HL - Exosomes, Blood, Brain Barrier, and Cognitive Function in Pediatric OSAR01HL130984 · NHLBI · UNIVERSITY OF MISSOURI-COLUMBIA · PI GOZAL, LEILA KHEIRANDISH · 2016 to 2020
$3.5M
A randomized controlled study of adenotonsillectomy for childrenU01HL083129 · NHLBI · UNIVERSITY OF PENNSYLVANIA · PI ELLENBERG, SUSAN S · 2006 to 2010
$2.5M
NCATS NIH HHS UL1 TR002548NCRR NIH HHS UL1 RR024134NCRR NIH HHS UL1 RR024989NHLBI NIH HHS R24 HL114473NHLBI NIH HHS U01 HL083075NHLBI NIH HHS U01 HL083129NIA NIH HHS RF1 AG061824NIH HHS HL130984University of Missouri HL140548
6 · The paper itself

Abstract

STUDY

objectivesPediatric obstructive sleep apnea (OSA) affects cardiac autonomic regulation, altering heart rate variability (HRV). Although changes in classical HRV parameters occur after OSA treatment, they have not been evaluated as reporters of OSA resolution. Specific frequency bands (named BW1, BW2, and BWRes) have been recently identified in OSA. We hypothesized that changes with treatment in these spectral bands can reliably identify changes in OSA severity and reflect OSA resolution.

methodsFour hundred and four OSA children (5-9.9 years) from the prospective Childhood Adenotonsillectomy Trial were included; 206 underwent early adenotonsillectomy (eAT), while 198 underwent watchful waiting with supportive care (WWSC). HRV changes from baseline to follow-up were computed for classical and OSA-related frequency bands. Causal mediation analysis was conducted to evaluate how treatment influences HRV through mediators such as OSA resolution and changes in disease severity. Disease resolution was initially assessed by considering only obstructive events, and was followed by adding central apneas to the analyses.

resultsTreatment, regardless of eAT or WWSC, affects HRV activity, mainly in the specific frequency band BW2 (0.028-0.074 Hz). Furthermore, only changes in BW2 were specifically attributable to all OSA resolution mediators. HRV activity in BW2 also showed statistically significant differences between resolved and non-resolved OSA.

conclusionsOSA treatment affects HRV activity in terms of change in severity and disease resolution, especially in OSA-related BW2 frequency band. This band allowed to differentiate HRV activity between children with and without resolution, so we propose BW2 as potential biomarker of pediatric OSA resolution. CLINICAL

trial registrationChildhood Adenotonsillectomy Trial, NCT00560859, https://sleepdata.org/datasets/chat.

Indexed as

Sleep Apnea, ObstructiveTonsillectomyAdenoidectomyBiomarkersChildChild, PreschoolHeart RateHumansProspective StudiesBiomarkersbiomarkercausal mediation analysisfrequency domain analysisheart rate variabilityobstructive sleep apnearesolutiontreatment

Identifiers

PMID34498074
PMCPMC8842334
OpenAlexW3196572421

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.