Evidence map›Paper›PMID 34498016›Full record

ArticleJournal of affective disorders reports2021

Mentalizing imagery therapy for depressed family dementia caregivers: Feasibility, clinical outcomes and brain connectivity changes.

Felipe A Jain, Sergey Chernyak, Lisa Nickerson, Michelle Abrams, Marco Iacoboni, Leonardo Christov-Moore, Colm G Connolly, Lauren B Fisher, Hitoshi Sakurai, Kate Bentley and 4 more

Registry-linked trialOpen access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of affective disorders reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT05253443 (Mobile App Delivered Mentalizing Imagery Therapy to Augment Remote Family Dementia Caregiver Skills Training), which is not on this map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.3field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT05253443 nacompletednot on this mapstarted 2024, after this paper: background citation

Mobile App Delivered Mentalizing Imagery Therapy to Augment Remote Family Dementia Caregiver Skills Training: a Pilot Randomized, Controlled Trial With Outcomes Assessment Using Digital Phenotyping

TypeinterventionalSponsorMassachusetts General HospitalRan2024 to 2025Enrolled135ConditionsFamily CaregiversArmsMentalizing Imagery Therapy and caregiver skills mobile application, Caregiver skills mobile application
3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 5 institutions in 1 country.

Felipe A JainDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Sergey ChernyakDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Lisa NickersonApplied Neuroimaging Statistics Laboratory, McLean Hospital, Harvard Medical School, Belmont, MA, United States.
Michelle AbramsSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States.
Marco IacoboniSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States.
Leonardo Christov-MooreSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States.
Colm G ConnollyDepartment of Biomedical Sciences, College of Medicine, Florida State University, Tallahassee, FL, United States.
Lauren B FisherDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Hitoshi SakuraiDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Kate BentleyDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Emily TanDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Michael PittmanDepression Clinical and Research Program, Department of Psychiatry, Massachusetts General Hospital, Harvard Medical School, Boston, MA, United States.
Helen LavretskySemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States.
Andrew F LeuchterSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, CA, United States.
University of California, Los Angeles · USHarvard University · USMassachusetts General Hospital · USFlorida State University · USMcLean Hospital · US

Funding

RESEARCH TRAINING: PSYCHOBIOLOGICAL SCIENCEST32MH017140 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI LEUCHTER, ANDREW F · 1985 to 2012
$3.2M
Mobile app delivered Mentalizing Imagery Therapy to augment remote family dementia caregiver skills training: a pilot randomized, controlled trial with outcomes assessment using digital phenotypingK76AG064390 · NIA · MASSACHUSETTS GENERAL HOSPITAL · PI JAIN, FELIPE A. · 2020 to 2024
$1.5M
NIA NIH HHS K76 AG064390NIMH NIH HHS T32 MH017140
6 · The paper itself

Abstract

backgroundFamily dementia caregivers experience high rates of depression and anxiety that often go untreated due to time demands. We aimed to determine the feasibility of a brief, 4-week Mentalizing Imagery Therapy intervention, which couples mindfulness with guided imagery practices aimed at bolstering mentalizing capacity, to reduce caregiver psychological symptoms and to explore potential impact on dorsolateral prefrontal cortex connectivity.

methodsTwenty-four family dementia caregivers with moderate depression symptoms (a score of 10 in Patient Health Questionnaire-9) were assigned to either group Mentalizing Imagery Therapy (MIT,

resultsEleven of 12 caregivers assigned to MIT completed the intervention and attended weekly groups 98% of the time. MIT home practice logs indicated average practice of 5 ± 2 sessions per week for 23 ± 8 min per session. All participants in waitlist completed the post-assessment. MIT participants exhibited significantly greater improvement than waitlist on self-reported depression and anxiety symptoms ( LIMITATIONS: Sample size limitations necessitate validation of findings in larger, randomized controlled trials.

conclusionsA 4-week group MIT program was feasible for caregivers, with high levels of participation in weekly group meetings and home practice exercises.

Indexed as

DementiaDepressionFamily caregiversMindfulnessNeuroimaging

Identifiers

PMID34498016
PMCPMC8423372
OpenAlexW3171069800

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.