Evidence map›Paper›PMID 34498003›Full record

ArticleRadiology. Cardiothoracic imaging2021

CT Morphologic Characteristics and Variant Patterns of Interstitial Pulmonary Fibrosis in Systemic Lupus Erythematosus.

Darragh Brady, Eugene A Berkowitz, Amita Sharma, Jeanne B Ackman, Adam Bernheim, Michael Chung, Srihari Veeraraghavan, Brent P Little

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Radiology. Cardiothoracic imaging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 27 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Darragh BradyDepartment of Radiology, Children's National Hospital, Washington, DC (D.B.); Department of Radiology and Imaging Sciences (E.A.B.) and Department of Medicine, Division of Pulmonary and Critical Care Medicine (S.V.), Emory University, Atlanta, Ga; Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.S., J.B.A., B.P.L.); and Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.B., M.C.).ORCID https://orcid.org/0000-0002-0877-8306
Eugene A BerkowitzDepartment of Radiology, Children's National Hospital, Washington, DC (D.B.); Department of Radiology and Imaging Sciences (E.A.B.) and Department of Medicine, Division of Pulmonary and Critical Care Medicine (S.V.), Emory University, Atlanta, Ga; Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.S., J.B.A., B.P.L.); and Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.B., M.C.).ORCID https://orcid.org/0000-0001-8371-230X
Amita SharmaDepartment of Radiology, Children's National Hospital, Washington, DC (D.B.); Department of Radiology and Imaging Sciences (E.A.B.) and Department of Medicine, Division of Pulmonary and Critical Care Medicine (S.V.), Emory University, Atlanta, Ga; Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.S., J.B.A., B.P.L.); and Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.B., M.C.).ORCID https://orcid.org/0000-0002-2510-4805
Jeanne B AckmanDepartment of Radiology, Children's National Hospital, Washington, DC (D.B.); Department of Radiology and Imaging Sciences (E.A.B.) and Department of Medicine, Division of Pulmonary and Critical Care Medicine (S.V.), Emory University, Atlanta, Ga; Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.S., J.B.A., B.P.L.); and Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.B., M.C.).ORCID https://orcid.org/0000-0001-5022-9530
Adam BernheimDepartment of Radiology, Children's National Hospital, Washington, DC (D.B.); Department of Radiology and Imaging Sciences (E.A.B.) and Department of Medicine, Division of Pulmonary and Critical Care Medicine (S.V.), Emory University, Atlanta, Ga; Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.S., J.B.A., B.P.L.); and Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.B., M.C.).ORCID https://orcid.org/0000-0001-9847-4498
Michael ChungDepartment of Radiology, Children's National Hospital, Washington, DC (D.B.); Department of Radiology and Imaging Sciences (E.A.B.) and Department of Medicine, Division of Pulmonary and Critical Care Medicine (S.V.), Emory University, Atlanta, Ga; Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.S., J.B.A., B.P.L.); and Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.B., M.C.).ORCID https://orcid.org/0000-0002-0976-4088
Srihari VeeraraghavanDepartment of Radiology, Children's National Hospital, Washington, DC (D.B.); Department of Radiology and Imaging Sciences (E.A.B.) and Department of Medicine, Division of Pulmonary and Critical Care Medicine (S.V.), Emory University, Atlanta, Ga; Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.S., J.B.A., B.P.L.); and Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.B., M.C.).ORCID https://orcid.org/0000-0002-0501-1994
Brent P LittleDepartment of Radiology, Children's National Hospital, Washington, DC (D.B.); Department of Radiology and Imaging Sciences (E.A.B.) and Department of Medicine, Division of Pulmonary and Critical Care Medicine (S.V.), Emory University, Atlanta, Ga; Department of Radiology, Massachusetts General Hospital, Boston, Mass (A.S., J.B.A., B.P.L.); and Department of Diagnostic, Molecular and Interventional Radiology, Icahn School of Medicine at Mount Sinai, New York, NY (A.B., M.C.).ORCID https://orcid.org/0000-0001-6657-8241
Mount Sinai Hospital · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo assess CT features of pulmonary fibrosis in patients with systemic lupus erythematosus (SLE) and to assess the presence of several distinctive patterns of fibrosis associated with connective tissue disease. MATERIALS AND

methodsA cross-sectional retrospective analysis was performed. An institutional clinical database was queried for the years of 2005-2015 to identify CT examination reports of patients with SLE and fibrotic lung disease, which yielded 50 patients (median age, 49 years; age range, 22-71 years; 46 women). CT examination reports were scored by two subspecialty thoracic radiologists using a standard multilevel semiquantitative system. Readers noted the presence or absence of several recently described CT signs of variant patterns of fibrosis in connective tissue disease (the "anterior upper lobe," "straight-edge," and "exuberant honeycombing" signs), as well as two other morphologic characteristics (an "island-like" appearance of areas of well-defined fibrosis with angular margins surrounded by normal lung and confluent regions of lucent lung destruction).

resultsThe most common CT patterns were characterized as either fibrotic nonspecific interstitial pneumonia (38%, 19 of 50) or variant fibrosis (44%, 22 of 50). CT signs of variant fibrosis were identified by both readers in up to 62% of patients, with good κ agreement (0.44-0.64); the island-like sign (62%) and anterior upper lobe sign (52%) were most commonly observed. Pulmonary function test results showed correlations with several imaging findings but did not show correlations with CT signs of variant fibrosis.

conclusionWhen present, pulmonary fibrosis in SLE often has a distinctive appearance and may also manifest as several variant fibrotic patterns.

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Identifiers

PMID34498003
PMCPMC8415141
OpenAlexW3194933948

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.