Evidence map›Paper›PMID 34497997›Full record

ArticleIJU case reports2021

Metastatic mucinous tubular and spindle cell carcinoma of the kidney responding to nivolumab plus ipilimumab.

Hirotaka Fuchizawa, Toshiki Kijima, Atsuko Takada-Owada, Yoji Nagashima, Akihito Okazaki, Megumi Yokoyama, Daisaku Nishihara, Kazuyuki Ishida, Takao Kamai

Abstract readCase Reports
In one paragraph

Article in IJU case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed.

  1. Article
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  6. [Mucinous tubular and spindle cell carcinoma of kidney: Clinicopathology and prognosis].Beijing da xue xue bao. Yi xue ban = Journal of Peking University. Health sciences · 2023
    Article
  7. A case report of mucinous tubular and spindle cell carcinoma of the kidney.American journal of clinical and experimental urology · 2023
    Article
  8. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Hirotaka FuchizawaDepartment of Urology Dokkyo Medical University Shimotsuga Tochigi Japan.
Toshiki KijimaDepartment of Urology Dokkyo Medical University Shimotsuga Tochigi Japan.ORCID https://orcid.org/0000-0002-4380-9294
Atsuko Takada-OwadaDepartment of Diagnostic Pathology Dokkyo Medical University Shimotsuga Tochigi Japan.
Yoji NagashimaDepartment of Surgical Pathology Tokyo Women's Medical University Tokyo Japan.
Akihito OkazakiDepartment of Urology Dokkyo Medical University Shimotsuga Tochigi Japan.
Megumi YokoyamaDepartment of Urology Dokkyo Medical University Shimotsuga Tochigi Japan.
Daisaku NishiharaDepartment of Urology Dokkyo Medical University Shimotsuga Tochigi Japan.
Kazuyuki IshidaDepartment of Diagnostic Pathology Dokkyo Medical University Shimotsuga Tochigi Japan.
Takao KamaiDepartment of Urology Dokkyo Medical University Shimotsuga Tochigi Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

introductionMucinous tubular and spindle cell carcinoma is a rare subtype of renal cell carcinoma. Little is known regarding the efficacy of systemic therapy on its metastatic form because of its rarity. CASE PRESENTATION: We present the case of a patient with metastatic mucinous tubular and spindle cell carcinoma who achieved durable complete remission of multiple osseous metastases after undergoing cytoreductive nephrectomy followed by combination immunotherapy (ipilimumab plus nivolumab). Immunohistochemical analyses of the primary tumor revealed the presence of the tumor-infiltrating immune cells, including activated CD8

conclusionCombination immunotherapy was a viable treatment option for this disease. Immunohistochemical analyses of the tumor-infiltrating immune cells predicted the efficacy of immune checkpoint inhibitors against rare renal cancers.

Indexed as

cytoreductive surgeryimmunotherapymucinous tubular and spindle cell carcinomanephrectomyrenal cell carcinoma

Identifiers

PMID34497997
PMCPMC8413205

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.