Evidence map›Paper›PMID 34497803›Full record

ArticleFrontiers in cell and developmental biology2021

Activation and Contraction of Human "Vascular" Smooth Muscle Cells Grown From Circulating Blood Progenitors.

Blerina Ahmetaj-Shala, Isra Marei, Ryota Kawai, Stephen Rothery, Charis Pericleous, Nura A Mohamed, Hime Gashaw, Kalliopi Bokea, Jake Samuel, Annabelle Vandenheste and 3 more

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cell and developmental biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 56% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 3 institutions in 3 countries.

Blerina Ahmetaj-ShalaNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Isra MareiNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Ryota KawaiNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Stephen RotheryFacility for Imaging by Light Microscopy, Faculty of Medicine, Imperial College London, London, United Kingdom.
Charis PericleousNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Nura A MohamedNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Hime GashawNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Kalliopi BokeaNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Jake SamuelNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Annabelle VandenhesteNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Fisnik ShalaNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Nicholas S KirkbyNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Jane A MitchellNational Heart and Lung Institute, Imperial College London, London, United Kingdom.
Imperial College London · GBQatar University · QAWeill Cornell Medical College in Qatar · QA

Funding

British Heart Foundation FS/16/1/31699Wellcome Trust
6 · The paper itself

Abstract

Blood outgrowth smooth muscle cells (BO-SMCs) offer the means to study vascular cells without the requirement for surgery providing opportunities for drug discovery, tissue engineering, and personalized medicine. However, little is known about these cells which meant that their therapeutic potential remains unexplored. Our objective was to investigate for the first time the ability of BO-SMCs and vessel-derived smooth muscle cells to sense the thromboxane mimetic U46619 by measuring intracellular calcium elevation and contraction. U46619 (10

Indexed as

blood vesselcalciumcontractionpersonalized medicinesmooth muscle progenitor cells

Identifiers

PMID34497803
PMCPMC8419454
OpenAlexW3194853864

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.