Evidence map›Paper›PMID 34497778›Full record

ArticleFrontiers in cellular and infection microbiology2021

Dual RNASeq Reveals NTHi-Macrophage Transcriptomic Changes During Intracellular Persistence.

Jodie Ackland, Ashley I Heinson, David W Cleary, Myron Christodoulides, Tom M A Wilkinson, Karl J Staples

Open access · goldAbstract read
In one paragraph

Article in Frontiers in cellular and infection microbiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
1.5field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 13 citations in OpenAlex.

  1. Trial
  2. ThemBio · 2026
    Article
  3. Review
  4. Inflammatory Responses to Non-TypeablePathogens (Basel, Switzerland) · 2025
    Article
  5. Macrophages and the microbiome in chronic obstructive pulmonary disease.European respiratory review : an official journal of the European Respiratory Society · 2024
    Review
  6. Hfe Permease andACS infectious diseases · 2024
    Article
  7. Persistent microbial infections and idiopathic pulmonary fibrosis - an insight intoFrontiers in cellular and infection microbiology · 2024
    Review
  8. Review
  9. Microbiology spectrum · 2023
    Article
  10. Article
  11. Non-typeableEuropean respiratory review : an official journal of the European Respiratory Society · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Jodie AcklandClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Ashley I HeinsonClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
David W ClearyClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Myron ChristodoulidesClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Tom M A WilkinsonClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Karl J StaplesClinical and Experimental Sciences, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
University of Southampton · GBSouthampton General Hospital · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Nontypeable

Indexed as

Haemophilus InfectionsHaemophilus influenzaeHumansMacrophagesSequence Analysis, RNATranscriptomedual RNAseqhost-pathogen interactionsintracellular persistencemacrophageNTHi

Identifiers

PMID34497778
PMCPMC8419319
OpenAlexW3196077126

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.