Evidence map›Paper›PMID 34497733›Full record

ArticleSleep medicine research2021

The Influence of Obesity on the Association of Obstructive Sleep Apnea and Atrial Fibrillation.

Patrick L Stafford, Evan K Harmon, Paras Patel, McCall Walker, Gen-Min Lin, Seung-Jung Park, Neal A Chatterjee, Nishaki K Mehta, Sula Mazimba, Kenneth Bilchick and 1 more

Open access · diamondAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Sleep medicine research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.5field-weighted citation impact, top 38% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 6 institutions in 2 countries.

Patrick L StaffordDepartment of Medicine, University of Virginia, Charlottesville, VA, USA.
Evan K HarmonDepartment of Medicine, University of Virginia, Charlottesville, VA, USA.
Paras PatelDepartment of Medicine, University of Virginia, Charlottesville, VA, USA.
McCall WalkerDepartment of Medicine, University of Texas- Southwestern, Dallas, TX, USA.
Gen-Min LinDepartment of Preventative Medicine, Northwestern University, Chicago, IL, USA; Department of Medicine, Hualien Armed Forces General Hospital, Hualien, Taiwan; Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan.
Seung-Jung ParkDepartment of Medicine, Heart Vascular Stroke Institute, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea.
Neal A ChatterjeeDepartment of Medicine, University of Washington, Seattle, WA, USA.
Nishaki K MehtaDepartment of Medicine, William Beaumont Hospital, Royal Oak, MI, USA.
Sula MazimbaDepartment of Medicine, University of Virginia, Charlottesville, VA, USA.
Kenneth BilchickDepartment of Medicine, University of Virginia, Charlottesville, VA, USA.
Younghoon KwonDepartment of Medicine, University of Washington, Seattle, WA, USA.
University of Virginia · USUniversity of Washington · USBeaumont Hospital, Royal Oak · USNorthwestern University · USSamsung Medical Center · KRThe University of Texas Southwestern Medical Center · US

Funding

Photoplethysmography Analysis to Assess Cardio-Cerebrovascular Impact of SleepR21AG070576 · NIA · UNIVERSITY OF WASHINGTON · PI KWON, YOUNGHOON · 2020 to 2021
$530k
Pulse Transit Time and Blood Pressure Trends during Sleep as Novel Cardiovascular MarkersR21HL140432 · NHLBI · UNIVERSITY OF VIRGINIA · PI KWON, YOUNGHOON · 2017 to 2018
$297k
Cardiovascular implications of sleep characteristics using real-world objective sleep dataR21HL150502 · NHLBI · UNIVERSITY OF WASHINGTON · PI KWON, YOUNGHOON, SOHN, MIN-WOONG · 2020 to 2021
$261k
NHLBI NIH HHS R21 HL140432NHLBI NIH HHS R21 HL150502NIA NIH HHS R21 AG070576
6 · The paper itself

Abstract

BACKGROUND AND

objectiveThe association between obstructive sleep apnea (OSA) and atrial fibrillation (AF) has been closely studied. However, obesity is a powerful confounder in the causal relationship between OSA and cardiovascular disease. The contribution of obesity in the relationship between OSA and AF remains unclear.

methodsWe recruited 457 consecutive patients equally with and without AF who underwent clinically indicated diagnostic polysomnography at a single academic sleep center. Multivariable logistic regression adjusting for age, sex, hypertension, and heart failure was performed to study the independent association between OSA and AF stratified by obesity.

resultsA total of 457 patients (male: 56.2%, mean age 63.1 ± 13.3 years) was included. OSA prevalence was similar between those with and without AF (52.6% vs. 47.4%, respectively; p = 0.24). In multivariable analysis, no association was found between AF and OSA regardless of obesity status. When severe OSA (vs. non-severe OSA) was modeled as a dependent variable, AF was associated with a higher likelihood of severe OSA in non-obese patients [odds ratio (OR): 2.29, 95% confidence interval (CI): 1.23-4.35, p = 0.01], but not in obese patients (OR: 0.95, 95% CI: 0.48-1.90, p = 0.89).

conclusionThe association of OSA with AF was present only in the non-obese and was limited to severe OSA patients. In contrast, no association was found in obese patients. The association between OSA and AF is partly dependent on the body habitus.

Indexed as

Atrial FibrillationObesityObstructive Sleep Apnea

Identifiers

PMID34497733
PMCPMC8423346
OpenAlexW3174368506

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.