Evidence map›Paper›PMID 34497611›Full record

ArticleFrontiers in immunology2021

MAIT Cells Balance the Requirements for Immune Tolerance and Anti-Microbial Defense During Pregnancy.

Johanna Raffetseder, Robert Lindau, Sigrid van der Veen, Göran Berg, Marie Larsson, Jan Ernerudh

Open access · goldAbstract read
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
1.0field-weighted citation impact, top 26% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it, 15 citations in OpenAlex.

  1. The dose- and time-dependent effectiveness and safety associated with COVID-19 vaccination during pregnancy: a systematic review and meta-analysis.International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases · 2023
    Pooled it
  2. Tuberculosis in Pregnancy: Challenges of Immune Protection.The Journal of infectious diseases · 2026
    Review
  3. Folic acid supplementation on congenital heart disease and its dual character.Current research in pharmacology and drug discovery · 2025
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Johanna RaffetsederDivision of Inflammation and Infection (II), Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Robert LindauDivision of Inflammation and Infection (II), Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Sigrid van der VeenDivision of Inflammation and Infection (II), Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Göran BergDivision of Obstetrics and Gynecology, and Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Marie LarssonDivision of Molecular Medicine and Virology (MMV), Department of Biomedical and Clinical Sciences (BKV), Linköping University, Linköping, Sweden.
Jan ErnerudhDepartment of Clinical Immunology and Transfusion Medicine, and Department of Biomedical and Clinical Sciences, Linköping University, Linköping, Sweden.
Linköping University · SE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Mucosal-associated invariant T (MAIT) cells are an innate-like T cell subset with proinflammatory and cytotoxic effector functions. During pregnancy, modulation of the maternal immune system, both at the fetal-maternal interface and systemically, is crucial for a successful outcome and manifests through controlled enhancement of innate and dampening of adaptive responses. Still, immune defenses need to efficiently protect both the mother and the fetus from infection. So far, it is unknown whether MAIT cells are subjected to immunomodulation during pregnancy, and characterization of decidual MAIT cells as well as their functional responses during pregnancy are mainly lacking. We here characterized the presence and phenotype of Vα7.2

Indexed as

Immune ToleranceLymphocyte CountBiomarkersDeciduaDisease ResistanceFemaleGene Expression RegulationGestational AgeHost-Pathogen InteractionsHumansImmunity, InnateImmunomodulationImmunophenotypingLymphocyte ActivationMucosal-Associated Invariant T CellsOrgan SpecificityBiomarkersanti-microbial responsedeciduaimmune toleranceimmunomodulationinnate-like T cellsmucosal-associated invariant T (MAIT) cellspregnancyT cells

Identifiers

PMID34497611
PMCPMC8420809
OpenAlexW3190521158

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.