Evidence map›Paper›PMID 34497603›Full record

ArticleFrontiers in immunology2021

Intracellular Accumulation of IFN-λ4 Induces ER Stress and Results in Anti-Cirrhotic but Pro-HCV Effects.

Olusegun O Onabajo, Fang Wang, Mei-Hsuan Lee, Oscar Florez-Vargas, Adeola Obajemu, Chizu Tanikawa, Joselin M Vargas, Shu-Fen Liao, Ci Song, Yu-Han Huang and 6 more

Open access · goldAbstract readVideo-Audio Media
PubMed Full text at PMC Publisher
In one paragraph

Article in Frontiers in immunology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.

0numbers the graph read from it
0cells of the map it votes in
11citing papers in PubMed
0.9field-weighted citation impact, top 24% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

11 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Article
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  4. Frequencies of anInternational journal of molecular sciences · 2024
    Article
  5. Review
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  8. Article
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  11. A Game of Infection - Song of Respiratory Viruses and Interferons.Frontiers in cellular and infection microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 6 institutions in 4 countries.

Olusegun O OnabajoLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Fang WangLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Mei-Hsuan LeeInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Oscar Florez-VargasLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Adeola ObajemuLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Chizu TanikawaInstitute of Medical Science, The University of Tokyo, Tokyo, Japan.
Joselin M VargasLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Shu-Fen LiaoInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Ci SongDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Yu-Han HuangInstitute of Clinical Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan.
Chen-Yang ShenInstitute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan.
A Rouf BandayLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Thomas R O'BrienInfections and Immunoepidemiology Branch, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Rockville, MD, United States.
Zhibin HuDepartment of Epidemiology, School of Public Health, Nanjing Medical University, Nanjing, China.
Koichi MatsudaGraduate School of Frontier Sciences, The University of Tokyo, Tokyo, Japan.
Ludmila Prokunina-OlssonLaboratory of Translational Genomics, Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, MD, United States.
Division of Cancer Epidemiology and GeneticsNational Cancer Institute · USNational Yang Ming Chiao Tung University · TWNanjing Medical University · CNThe University of Tokyo · JPInstitute of Biomedical Sciences, Academia Sinica · TW

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Endoplasmic Reticulum StressAdultApoptosisCarcinoma, HepatocellularCase-Control StudiesCell ProliferationDatabases, FactualFemaleGenetic Predisposition to DiseaseHepatitis CHep G2 CellsHumansInterferon LambdaInterferonsInterleukinsJapanIFNL4 protein, humanInterferon Lambdainterferon-lambda, humanInterferonsInterleukinsER stressHCC (hepatocellular carcinoma)HCV (Hepatitis C)IFNL4liver cirrhosis

Identifiers

PMID34497603
PMCPMC8419317
OpenAlexW3195425819

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.