Evidence map›Paper›PMID 34497546›Full record

ArticleFrontiers in psychiatry2021

fMRI Neurofeedback-Enhanced Cognitive Reappraisal Training in Depression: A Double-Blind Comparison of Left and Right vlPFC Regulation.

Micha Keller, Jana Zweerings, Martin Klasen, Mikhail Zvyagintsev, Jorge Iglesias, Raul Mendoza Quiñones, Klaus Mathiak

Registry-linked trialOpen access · goldAbstract read
In one paragraph

Article in Frontiers in psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT06866028 (Enhancing Emotion Regulation Through fNIRS-informed Real-time Neurofeedback), which is not on this map. Cited by 22 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 5 pooled it
2.6field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT06866028 narecruitingnot on this mapstarted 2024, after this paper: background citation

Enhancing Emotion Regulation Through fNIRS-informed Real-time Neurofeedback

TypeinterventionalSponsorUniversity of Electronic Science and Technology of ChinaRan2024 to 2026Enrolled50ConditionsNeurofeedback, Emotion Regulation, StressArmsReal-time fNIRS neurofeedback from Turbo-Satori, Yoked sham feedback from Turbo-Satori
3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 5 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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  10. Effectiveness of fMRI-based Neurofeedback Therapy on Depression: A Systematic Review.Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Micha KellerDepartment of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine, RWTH Aachen University, Aachen, Germany.
Jana ZweeringsDepartment of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine, RWTH Aachen University, Aachen, Germany.
Martin KlasenDepartment of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine, RWTH Aachen University, Aachen, Germany.
Mikhail ZvyagintsevDepartment of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine, RWTH Aachen University, Aachen, Germany.
Jorge IglesiasDepartment of Cognitive Neuroscience, Cuban Center for Neuroscience, Havana, Cuba.
Raul Mendoza QuiñonesDepartment of Cognitive Neuroscience, Cuban Center for Neuroscience, Havana, Cuba.
Klaus MathiakDepartment of Psychiatry, Psychotherapy and Psychosomatics, School of Medicine, RWTH Aachen University, Aachen, Germany.
RWTH Aachen University · DECuban Neuroscience Center · CUJülich Aachen Research Alliance · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Affective disorders are associated with maladaptive emotion regulation strategies. In particular, the left more than the right ventrolateral prefrontal cortex (vlPFC) may insufficiently regulate emotion processing, e.g., in the amygdala. A double-blind cross-over study investigated NF-supported cognitive reappraisal training in major depression (

Indexed as

cognitive reappraisaldepressionemotion regulationlateral PFCreal-time fMRI neurofeedback

Identifiers

PMID34497546
PMCPMC8419460
OpenAlexW3194568957

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.