Evidence map›Paper›PMID 34497496›Full record

ArticleFrontiers in behavioral neuroscience2021

Glutamatergic Neurotransmission Controls the Functional Lateralization of the mPFC in the Modulation of Anxiety Induced by Social Defeat Stress in Male Mice.

Nathália Santos-Costa, Daniela Baptista-de-Souza, Lucas Canto-de-Souza, Vinícius Fresca da Costa, Ricardo Luiz Nunes-de-Souza

Open access · goldAbstract read
In one paragraph

Article in Frontiers in behavioral neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 33% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 16 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Nathália Santos-CostaLaboratory of Pharmacology, School of Pharmaceutical Sciences, Universidade Estadual Paulista, Araraquara, Brazil.
Daniela Baptista-de-SouzaLaboratory of Pharmacology, School of Pharmaceutical Sciences, Universidade Estadual Paulista, Araraquara, Brazil.
Lucas Canto-de-SouzaLaboratory of Pharmacology, School of Pharmaceutical Sciences, Universidade Estadual Paulista, Araraquara, Brazil.
Vinícius Fresca da CostaLaboratory of Pharmacology, School of Pharmaceutical Sciences, Universidade Estadual Paulista, Araraquara, Brazil.
Ricardo Luiz Nunes-de-SouzaLaboratory of Pharmacology, School of Pharmaceutical Sciences, Universidade Estadual Paulista, Araraquara, Brazil.
Universidade Estadual Paulista (Unesp) · BRUniversidade Federal de São Carlos · BR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The rodent medial prefrontal cortex (mPFC) is anatomically divided into cingulate (Cg1), prelimbic (PrL), and infralimbic (IL) subareas. The left and right mPFC (L and RmPFC) process emotional responses induced by stress-related stimuli, and LmPFC and RmPFC inhibition elicit anxiogenesis and anxiolysis, respectively. Here we sought to investigate (i) the mPFC functional laterality on social avoidance/anxiogenic-like behaviors in male mice subjected to chronic social defeat stress (SDS), (ii) the effects of left prelimbic (PrL) inhibition (with local injection of CoCl

Indexed as

anxietyCaMKIIchronic social defeat stressglutamatergic neurotransmissionmicemPFCΔFosB

Identifiers

PMID34497496
PMCPMC8419264
OpenAlexW3193721382

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.