Evidence map›Paper›PMID 34497447›Full record

Observational studyWorld journal of gastroenterology2021

Establishment and validation of a computer-assisted colonic polyp localization system based on deep learning.

Sheng-Bing Zhao, Wei Yang, Shu-Ling Wang, Peng Pan, Run-Dong Wang, Xin Chang, Zhong-Qian Sun, Xing-Hui Fu, Hong Shang, Jian-Rong Wu and 17 more

Open access · greenAbstract readMulticenter StudyObservational Study
In one paragraph

Observational study in World journal of gastroenterology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 13 citations in OpenAlex.

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  5. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 3 institutions in 1 country.

Sheng-Bing ZhaoChanghai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Wei YangTencent AI Lab, National Open Innovation Platform for Next Generation Artificial Intelligence on Medical Imaging, Shenzhen 518063, Guangdong Province, China.
Shu-Ling WangDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Peng PanDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Run-Dong WangDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Xin ChangDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Zhong-Qian SunTencent AI Lab, National Open Innovation Platform for Next Generation Artificial Intelligence on Medical Imaging, Shenzhen 518063, Guangdong Province, China.
Xing-Hui FuTencent AI Lab, National Open Innovation Platform for Next Generation Artificial Intelligence on Medical Imaging, Shenzhen 518063, Guangdong Province, China.
Hong ShangTencent AI Lab, National Open Innovation Platform for Next Generation Artificial Intelligence on Medical Imaging, Shenzhen 518063, Guangdong Province, China.
Jian-Rong WuTencent Healthcare (Shenzhen) Co. LTD., Shenzhen 518063, Guangdong Province, China.
Li-Zhu ChenTencent Healthcare (Shenzhen) Co. LTD., Shenzhen 518063, Guangdong Province, China.
Jia ChangTencent Healthcare (Shenzhen) Co. LTD., Shenzhen 518063, Guangdong Province, China.
Pu SongTencent Healthcare (Shenzhen) Co. LTD., Shenzhen 518063, Guangdong Province, China.
Ying-Lei MiaoDepartment of Gastroenterology, The First Affiliated Hospital of Kunming Medical University, Kunming 650000, Yunnan Province, China.
Shui-Xiang HeDepartment of Gastroenterology, The First Affiliated Hospital of Xi'an Jiaotong University, Xi'an 710061, Shaanxi Province, China.
Lin MiaoInstitute of Digestive Endoscopy and Medical Center for Digestive Disease, The Second Affiliated Hospital of Nanjing Medical University, Nanjing 210011, Jiangsu Province, China.
Hui-Qing JiangDepartment of Gastroenterology, The Second Hospital of Hebei Medical University, Hebei Key Laboratory of Gastroenterology, Hebei Institute of Gastroenterology, Shijiazhuang 050000, Hebei Province, China.
Wen WangDepartment of Gastroenterology, 900 Hospital of Joint Logistics Support Force, Fuzhou 350025, Fujian Province, China.
Xia YangDepartment of Gastroenterology, No. 905 Hospital of The Chinese People's Liberation Army, Shanghai 200050, China.
Yuan-Hang DongDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Han LinDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Yan ChenDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Jie GaoDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Qian-Qian MengDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Zhen-Dong JinDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Zhao-Shen LiDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China.
Yu BaiDepartment of Gastroenterology, Changhai Hospital, Second Military Medical University/Naval Medical University, Shanghai 200433, China. baiyu1998@hotmail.com.
Second Military Medical University · CNChanghai Hospital · CNFirst Affiliated Hospital of Xi'an Jiaotong University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundArtificial intelligence in colonoscopy is an emerging field, and its application may help colonoscopists improve inspection quality and reduce the rate of missed polyps and adenomas. Several deep learning-based computer-assisted detection (CADe) techniques were established from small single-center datasets, and unrepresentative learning materials might confine their application and generalization in wide practice. Although CADes have been reported to identify polyps in colonoscopic images and videos in real time, their diagnostic performance deserves to be further validated in clinical practice.

aimTo train and test a CADe based on multicenter high-quality images of polyps and preliminarily validate it in clinical colonoscopies.

methodsWith high-quality screening and labeling from 55 qualified colonoscopists, a dataset consisting of over 71000 images from 20 centers was used to train and test a deep learning-based CADe. In addition, the real-time diagnostic performance of CADe was tested frame by frame in 47 unaltered full-ranged videos that contained 86 histologically confirmed polyps. Finally, we conducted a self-controlled observational study to validate the diagnostic performance of CADe in real-world colonoscopy with the main outcome measure of polyps per colonoscopy in Changhai Hospital.

resultsThe CADe was able to identify polyps in the test dataset with 95.0% sensitivity and 99.1% specificity. For colonoscopy videos, all 86 polyps were detected with 92.2% sensitivity and 93.6% specificity in frame-by-frame analysis. In the prospective validation, the sensitivity of CAD in identifying polyps was 98.4% (185/188). Folds, reflections of light and fecal fluid were the main causes of false positives in both the test dataset and clinical colonoscopies. Colonoscopists can detect more polyps (0.90

conclusionCADe is feasible in the clinical setting and might help endoscopists detect more polyps and adenomas, and further confirmation is warranted.

Indexed as

Colonic PolypsDeep LearningArtificial IntelligenceColonoscopyComputersHumansArtificial intelligenceClinical validationColonoscopyColorectal polypComputer-assisted detectionDeep learning

Identifiers

PMID34497447
PMCPMC8384745
OpenAlexW3194181762

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.