ArticleNature2021
Positive allosteric mechanisms of adenosine A
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In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 98 papers.
0numbers the graph read from it
0cells of the map it votes in
98citing papers in PubMed
10.2field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
98 citing papers in PubMed, 156 citations in OpenAlex.
- G Protein-Mediated Allosteric Modulation of Ligand Binding in Class A GPCRs: Receptor-Ligand-Transducer Ensembles in Disease and Drug Discovery.Pharmaceuticals (Basel, Switzerland) · 2026Review
- Natural chlocarbazomycins as potential adenosine A1 receptor antagonists: ligand-based and structure-based virtual screening, quantum chemical analysis and CNS MPO study.Molecular diversity · 2026Article
- Molecular mechanism of allosteric modulation of opioid receptors.Signal transduction and targeted therapy · 2026Article
- Mismatch negativity-like responses in nitroglycerin-elicited migraine model.Scientific reports · 2026Article
- From empirical screening to lipid trolling: the evolution of extrahelical allosteric modulators of AMedicinal chemistry research : an international journal for rapid communications on design and mechanisms of action of biologically active agents · 2026Review
- Two-Step Ligand-Directed Covalent Fluorescent Labeling of the Adenosine AJournal of medicinal chemistry · 2026Article
- Structural Perspectives on Biased Allostery of GPCR Signaling.Handbook of experimental pharmacology · 2026Review
- The Concise Guide to PHARMACOLOGY 2025/26: G protein-coupled receptors.British journal of pharmacology · 2025Review
- Dissociation kinetics of G proteins from G protein-coupled receptors and effects of allosteric modulation.Proceedings of the National Academy of Sciences of the United States of America · 2025Article
- Conformational Heterogeneity Underlying Divergent Signaling in Class A G Protein-Coupled Receptors.ACS pharmacology & translational science · 2025Review
- Bitopic AJournal of medicinal chemistry · 2025Article
- Molecular basis of ligand binding and receptor activation at the human ANature communications · 2025Article
- Arrestin-biased allosteric modulator of neurotensin receptor 1 alleviates acute and chronic pain.Cell · 2025Article
- Caffeine: a potential mechanism for anti-obesity.Purinergic signalling · 2025Review
- Structure-based discovery of positive allosteric modulators of the AProceedings of the National Academy of Sciences of the United States of America · 2025Article
- Article
- Narcotics through time: exploring historical origins, synthetic advances, and clinical progress.Future medicinal chemistry · 2025Review
- Deciphering adenosine signaling in hepatocellular carcinoma: Pathways, prognostic models, and therapeutic implications.Clinical and molecular hepatology · 2025Review
- Valerenic Acid and Pinoresinol as Positive Allosteric Modulators: Unlocking the Sleep-Promoting Potential of Valerian Extract Ze 911.Molecules (Basel, Switzerland) · 2025Article
- Structural insights into lipid chain-length selectivity and allosteric regulation of FFA2.Nature communications · 2025Article
38 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
24 authors at 8 institutions in 4 countries.
Christopher J Draper-JoyceDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0003-2055-7706
Rebecca BholaDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Jinan WangCenter for Computational Biology and Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA.ORCID http://orcid.org/0000-0003-0162-212X
Apurba BhattaraiCenter for Computational Biology and Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA.
Anh T N NguyenDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
India Cowie-KentDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.
Kelly O'SullivanDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia.ORCID http://orcid.org/0000-0003-1715-595X
Ling Yeong ChiaDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Hariprasad VenugopalDepartment of Biochemistry and Molecular Biology, Monash University, Clayton, Victoria, Australia.
Celine ValantDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
David M ThalDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0002-0325-2524
Denise WoottenDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Nicolas PanelScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.ORCID http://orcid.org/0000-0001-8782-0586
Jens CarlssonScience for Life Laboratory, Department of Cell and Molecular Biology, Uppsala University, Uppsala, Sweden.
Macdonald J ChristieDiscipline of Pharmacology, Faculty of Medicine and Health, University of Sydney, Camperdown, New South Wales, Australia.ORCID http://orcid.org/0000-0002-0622-609X
Paul J WhiteDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Peter ScammellsMedicinal Chemistry, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Lauren T MayDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.
Patrick M SextonDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia.ORCID http://orcid.org/0000-0001-8902-2473
Radostin DanevGraduate School of Medicine, University of Tokyo, Tokyo, Japan.ORCID http://orcid.org/0000-0001-6406-8993
Yinglong MiaoCenter for Computational Biology and Department of Molecular Biosciences, University of Kansas, Lawrence, KS, USA.ORCID http://orcid.org/0000-0003-3714-1395
Alisa GlukhovaDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. glukhova.a@wehi.edu.au.ORCID http://orcid.org/0000-0003-4146-965X
Wendy L ImlachDepartment of Physiology, Monash Biomedicine Discovery Institute, Monash University, Clayton, Victoria, Australia. wendy.imlach@monash.edu.ORCID http://orcid.org/0000-0002-7521-9969
Arthur ChristopoulosDrug Discovery Biology and Department of Pharmacology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia. arthur.christopoulos@monash.edu.ORCID http://orcid.org/0000-0003-4442-3294
Monash University · AUAustralian Regenerative Medicine Institute · AUUniversity of Kansas · USDiscovery Institute · USThe University of Melbourne · AUUppsala University · SEThe University of Sydney · AUThe University of Tokyo · JP
Funding
Enhanced Sampling of G-Protein-Coupled Receptor-G Protein InteractionsR01GM132572 · NIGMS · UNIV OF NORTH CAROLINA CHAPEL HILL · PI MIAO, YINGLONG · 2019 to 2023
$1.5MAmerican Heart Association-American Stroke Association 17SDG33370094NIGMS NIH HHS R01 GM132572
Abstract
The adenosine A
Indexed as
AnalgesiaAdenosineAllosteric RegulationAnimalsBinding SitesDisease Models, AnimalFemaleGTP-Binding Protein alpha Subunit, Gi2HyperalgesiaLipidsMaleNeuralgiaProtein StabilityRatsRats, Sprague-DawleyReceptor, Adenosine A1AdenosineGTP-Binding Protein alpha Subunit, Gi2LipidsReceptor, Adenosine A1
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.