Evidence map›Paper›PMID 34497421›Full record

ArticleNature2021

A lymphocyte-microglia-astrocyte axis in chronic active multiple sclerosis.

Martina Absinta, Dragan Maric, Marjan Gharagozloo, Thomas Garton, Matthew D Smith, Jing Jin, Kathryn C Fitzgerald, Anya Song, Poching Liu, Jing-Ping Lin and 6 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 472 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
472citing papers in PubMed, 2 pooled it
48.5field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

472 citing papers in PubMed, 2 syntheses or guidelines pooled it, 725 citations in OpenAlex.

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412 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

16 authors at 3 institutions in 2 countries.

Martina AbsintaDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA. mabsint1@jhmi.edu.ORCID http://orcid.org/0000-0003-0276-383X
Dragan MaricFlow and Imaging Cytometry Core Facility, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-2912-7921
Marjan GharagozlooDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0002-2166-4012
Thomas GartonDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0001-9352-8530
Matthew D SmithDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Jing JinDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-1508-8036
Kathryn C FitzgeraldDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.ORCID http://orcid.org/0000-0003-3137-0322
Anya SongDepartment of Neurobiology and the Brudnik Neuropsychiatry Institute, University of Massachusetts Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0002-0885-7530
Poching LiuDNA Sequencing and Genomics Core, National Heart, Lung, and Blood Institute, National Institutes of Health, Bethesda, MD, USA.
Jing-Ping LinTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0003-0686-0215
Tianxia WuClinical Trials Unit, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Kory R JohnsonBioinformatics Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.
Dorian B McGavernViral Immunology and Intravital Imaging Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA.ORCID http://orcid.org/0000-0001-9568-545X
Dorothy P SchaferDepartment of Neurobiology and the Brudnik Neuropsychiatry Institute, University of Massachusetts Medical School, Worcester, MA, USA.ORCID http://orcid.org/0000-0003-2201-6276
Peter A CalabresiDepartment of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
Daniel S ReichTranslational Neuroradiology Section, National Institute of Neurological Disorders and Stroke, National Institutes of Health, Bethesda, MD, USA. daniel.reich@nih.gov.ORCID http://orcid.org/0000-0002-2628-4334
National Institutes of Health · USJohns Hopkins University · USUniversity of Massachusetts Chan Medical School · US

Funding

Multimodal MRI in Multiple SclerosisZIANS003119 · NINDS · NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE · PI REICH, DANIEL · 2010 to 2025
$53.4M
Medical Scientist Training ProgramT32GM136577 · NIGMS · JOHNS HOPKINS UNIVERSITY · PI ANDREA L COX · 2020 to 2026
$13.4M
Imaging Neurodegeneration in Multiple SclerosisR01NS082347 · NINDS · JOHNS HOPKINS UNIVERSITY · PI PETER A CALABRESI, Shiv Saidha · 2013 to 2026
$7.0M
Pathogenesis of Neurological Disability in Primary Diseases of MyelinR35NS097303 · NINDS · CLEVELAND CLINIC LERNER COM-CWRU · PI TRAPP, BRUCE D · 2017 to 2024
$6.9M
The Role of KV1.3 in Effector T cellsR01NS041435 · NINDS · UNIVERSITY OF MARYLAND BALTIMORE · PI CALABRESI, PETER A · 2000 to 2025
$5.8M
How Do Synaptic Connections Change in Demyelinating Disease?R01NS117533 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA · 2021 to 2025
$2.2M
Dissecting the impact of senescence on microglia function and neurodegenerationRF1AG068281 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA, ZHANG, HONG · 2020 to 2020
$1.7M
Dissecting the impact of senescence on microglia function and neurodegenerationR01AG068281 · NIA · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI SCHAFER, DOROTHY PATRICIA, ZHANG, HONG · 2024 to 2024
$419k
Intramural NIH HHS ZIA NS003119Intramural NIH HHS ZIA NS003148NIA NIH HHS R01 AG068281NIGMS NIH HHS T32 GM136577NINDS NIH HHS R01 NS041435NINDS NIH HHS R01 NS082347NINDS NIH HHS R01 NS117533NINDS NIH HHS R35 NS097303
6 · The paper itself

Abstract

Multiple sclerosis (MS) lesions that do not resolve in the months after they form harbour ongoing demyelination and axon degeneration, and are identifiable in vivo by their paramagnetic rims on MRI scans

Indexed as

AnimalsAstrocytesBrainComplement C1qEncephalomyelitis, Autoimmune, ExperimentalFemaleHumansInflammationLymphocytesMagnetic Resonance ImagingMaleMiceMice, Inbred C57BLMicrogliaMiddle AgedMultiple SclerosisComplement C1q

Identifiers

PMID34497421
PMCPMC8719282
OpenAlexW3197136220

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.