ArticleNature2021
Bioaccumulation of therapeutic drugs by human gut bacteria.
Open access · greenAbstract read
In one paragraph
Article in Nature, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 183 papers, 1 of them a synthesis that pooled it.
0numbers the graph read from it
0cells of the map it votes in
183citing papers in PubMed, 1 pooled it
19.0field-weighted citation impact, top 1% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
183 citing papers in PubMed, 1 synthesis or guideline pooled it, 291 citations in OpenAlex.
- Research status and development trends of probiotics in clinical applications.Frontiers in nutrition · 2025Pooled it
- Microbes and medicines: interrelationships between pharmaceuticals and the gut microbiome.Gut microbes · 2026Review
- Gut microbial metabolism of Flutamide attenuates its therapeutic efficacy against prostate cancer.Gut microbes · 2026Article
- Obstetric Pharmacomicrobiomics.Clinical pharmacology and therapeutics · 2026Review
- Microbiome ecology and antibiotic treatment failure: resistance spread, microbial competition and community engineering.Microbial genomics · 2026Review
- Decoding the cancer microbiome: multi-omics, AI, and translational opportunities.Genome biology · 2026Review
- Drug-microbiome-host interactions: antimicrobial effects of non-antibiotic compounds.Nature reviews. Gastroenterology & hepatology · 2026Review
- Common xenobiotics modulate gut microbial responses to low‑calorie sweeteners in vitro.Molecular systems biology · 2026Article
- Prediction of bacteria-specific drug metabolism using a cross-attention-based model.Briefings in bioinformatics · 2026Article
- Symbiotic Stenotrophomonas maltophilia is associated with ivermectin resistance in the parasitic nematode Haemonchus contortus via metabolic detoxification.International journal for parasitology. Drugs and drug resistance · 2026Article
- The effect of SSRI/SNRI antidepressant treatment on the gut microbiota of patients with major depressive disorder.Communications medicine · 2026Article
- The microbiome regulates host metabolic health and diseases through microbial enzymes.Nature reviews. Gastroenterology & hepatology · 2026Review
- From diet to function: using synthetic microbial communities to map gut microbial interactions.NPJ biofilms and microbiomes · 2026Review
- O-GlcNAcylation licenses RNF166 to degrade the M protein of porcine coronaviruses.PLoS pathogens · 2026Article
- Modular design for drug delivery across hierarchical gastrointestinal barriers: From materials to systems.Materials today. Bio · 2026Review
- Harnessing the microbiome for cancer therapy.Nature reviews. Microbiology · 2026Review
- Pharmacomicrobiomics of Non-Antibiotic Drugs: Mechanisms and Clinical Consequences of Gut Microbiota Alterations.Pharmaceutics · 2026Review
- Review
- Probiotics mitigate non-antibiotic drug-induced dysbiosis via protein homology-driven competitive binding.Nature communications · 2026Article
- Microbiome-Modulating Strategies in Anticancer Therapy: A Review of Current Evidence and Recommendations for Further Treatment Improvement.Probiotics and antimicrobial proteins · 2026Review
123 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
34 authors at 13 institutions in 5 countries.
Martina Klünemann *European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-1602-5371
Sergej Andrejev *European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7875-0261
Sonja Blasche *European Molecular Biology Laboratory, Heidelberg, Germany.
Andre Mateus *European Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6870-0677
Prasad PhapaleEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9487-597X
Saravanan DevendranEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Johanna VappianiCellzome, GlaxoSmithKline R&D, Heidelberg, Germany.
Bernd SimonEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Timothy A ScottInstitute of Structural and Molecular Biology, University College London, London, UK.
Eleni KafkiaMedical Research Council Toxicology Unit, Cambridge, UK.ORCID http://orcid.org/0000-0001-9550-4487
Dimitrios KonstantinidisEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Katharina ZirngiblEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Eleonora MastrorilliEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2127-4150
Manuel BanzhafEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Marie-Therese MackmullEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2928-1144
Felix HövelmannEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Leo NesmeEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Ana Rita BrochadoEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Lisa MaierEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-6473-4762
Thomas BockEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-9314-5318
Vinita PeriwalEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Manjeet KumarEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Yongkyu KimEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-3336-6741
Melanie TramontanoEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-6407-527X
Carsten SchultzEuropean Molecular Biology Laboratory, Heidelberg, Germany.
Martin BeckEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-7397-1321
Janosch HennigEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0001-5214-7002
Michael ZimmermannEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0002-5797-3589
Daniel C SévinCellzome, GlaxoSmithKline R&D, Heidelberg, Germany.
Filipe CabreiroInstitute of Structural and Molecular Biology, University College London, London, UK.ORCID http://orcid.org/0000-0002-3696-4843
Mikhail M SavitskiEuropean Molecular Biology Laboratory, Heidelberg, Germany.ORCID http://orcid.org/0000-0003-2011-9247
Peer BorkEuropean Molecular Biology Laboratory, Heidelberg, Germany. bork@embl.de.ORCID http://orcid.org/0000-0002-2627-833X
Athanasios TypasEuropean Molecular Biology Laboratory, Heidelberg, Germany. typas@embl.de.ORCID http://orcid.org/0000-0002-0797-9018
Kiran R PatilEuropean Molecular Biology Laboratory, Heidelberg, Germany. kp533@cam.ac.uk.ORCID http://orcid.org/0000-0002-6166-8640
European Molecular Biology Laboratory · DEGerman Cancer Research Center · DEGlaxoSmithKline (Germany) · DEETH Zurich · CHEvonik (Germany) · DEInstitute of Structural and Molecular Biology · GBMax Planck Institute of Biophysics · DEMedical Research Council · GBOregon Health & Science University · USTH Köln - University of Applied Sciences · DEUniversity of Basel · CHUniversity of Würzburg · DEYonsei University · KR
Funding
Medical Research Council MC_UP_1605/6Medical Research Council MC_UU_00025/11
Abstract
Bacteria in the gut can modulate the availability and efficacy of therapeutic drugs. However, the systematic mapping of the interactions between drugs and bacteria has only started recently
Indexed as
BioaccumulationAnimalsAntidepressive AgentsBacteriaCaenorhabditis elegansCellsClick ChemistryDuloxetine HydrochlorideGastrointestinal MicrobiomeHumansMetabolomicsModels, AnimalProteomicsReproducibility of ResultsAntidepressive AgentsDuloxetine Hydrochloride
Identifiers
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.