Evidence map›Paper›PMID 34497367›Full record

ArticleLaboratory investigation; a journal of technical methods and pathology2022

Increased transient receptor potential canonical 3 activity is involved in the pathogenesis of detrusor overactivity by dynamic interaction with Na

Jingzhen Zhu, Yi Fan, Qudong Lu, Yang Yang, Hui Li, Xin Liu, Hengshuai Zhang, Bishao Sun, Qian Liu, Jiang Zhao and 4 more

Abstract read
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In one paragraph

Article in Laboratory investigation; a journal of technical methods and pathology, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
0.1field-weighted citation impact, top 61% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 2 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 1 institution in 1 country.

Jingzhen ZhuDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Yi FanDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Qudong LuDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Yang YangDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Hui LiDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Xin LiuDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Hengshuai ZhangDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Bishao SunDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Qian LiuDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Jiang ZhaoDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Zhenxing YangDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Longkun LiDepartment of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China.
Huan Feng *Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China. fenghuan@tmmu.edu.cn.
Jie Xu *Department of Urology, Second Affiliated Hospital, Army Medical University, Chongqing, China. xujie1981@tmmu.edu.cn.ORCID 0000-0001-6700-7096
Army Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Transient receptor potential canonical 3 (TRPC3) is a nonselective cation channel, and its dysfunction is the basis of many clinical diseases. However, little is known about its possible role in the bladder. The purpose of this study was to explore the function and mechanism of TRPC3 in partial bladder outlet obstruction (PBOO)-induced detrusor overactivity (DO). We studied 31 adult female rats with DO induced by PBOO (the DO group) and 40 sham-operated rats (the control group). Here we report that the expression of TRPC3 in the bladder of DO rats increased significantly. Furthermore, PYR10, which can selectively inhibit the TRPC3 channel, significantly reduced bladder excitability in DO and control rats, but the decrease of the bladder excitability of DO rats was more obvious. PYR10 significantly reduced the intracellular calcium concentration in smooth muscle cells (SMCs) in DO and control rats. Finally, Na

Indexed as

Gene Expression RegulationAniline CompoundsAnimalsCalciumCells, CulturedDisease Models, AnimalFemaleHumansMyocytes, Smooth MusclePhenyl EthersProtein BindingRatsReverse Transcriptase Polymerase Chain ReactionSodium-Calcium ExchangerTRPC Cation ChannelsUrinary BladderAniline CompoundsCalciumPhenyl EthersSEA 0400Sodium-Calcium Exchangersodium-calcium exchanger 1TRPC3 cation channelTRPC Cation Channels

Identifiers

PMID34497367
OpenAlexW3196701673

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.