ArticleInternational journal of obesity (2005)2022
Estimating the influence of body mass index (BMI) on mortality using offspring BMI as an instrumental variable.
Article in International journal of obesity (2005), 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.
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Who cites it
6 citing papers in PubMed.
- Six anthropometric indices and all-cause mortality in ageing populations: an observational cohort study in six longitudinal studies.BMC public health · 2026Observational
- An instrumental variable analysis of body mass index and risk of long-term sick leave: the HUNT Study, Norway.European journal of epidemiology · 2025Article
- Liver at crossroads: unraveling the links between obesity, chronic liver diseases, and the mysterious obesity paradox.Clinical and experimental medicine · 2024Review
- The healthcare costs of increased body mass index-evidence from The Trøndelag Health Study.Health economics review · 2024Article
- Body mass index and all-cause mortality in HUNT and UK biobank studies: revised non-linear Mendelian randomisation analyses.BMJ open · 2024Article
- Fiber Consumption Mediates Differences in Several Gut Microbes in a Subpopulation of Young Mexican Adults.Nutrients · 2022Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
objectiveHigh body mass index (BMI) is an important predictor of mortality but estimating underlying causality is hampered by confounding and pre-existing disease. Here, we use information from the offspring to approximate parental BMIs, with an aim to avoid biased estimation of mortality risk caused by reverse causality.
methodsThe analyses were based on information on 9674 offspring-mother and 9096 offspring-father pairs obtained from the 1958 British birth cohort. Parental BMI-mortality associations were analysed using conventional methods and using offspring BMI as a proxy, or instrument, for their parents' BMI.
resultsIn the conventional analysis, associations between parental BMI and all-cause mortality were U-shaped (P
conclusionsAnalyses using offspring BMI as a proxy for parental BMI suggest that the apparent adverse consequences of low BMI are considerably overestimated and adverse consequences of overweight are underestimated in conventional epidemiological studies.
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