Evidence map›Paper›PMID 34497172›Full record

ArticleJournal of atherosclerosis and thrombosis2022

Atherogenic Index of Plasma and the Risk of In-Stent Restenosis in Patients with Acute Coronary Syndrome beyond the Traditional Risk Factors.

Yong Zhu, Maolin Chen, Kesen Liu, Ang Gao, Xiangyun Kong, Yan Liu, Hongya Han, Hong Li, Huagang Zhu, Jianwei Zhang and 1 more

Open access · diamondAbstract read
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Article in Journal of atherosclerosis and thrombosis, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed, 2 pooled it
4.8field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 2 syntheses or guidelines pooled it, 34 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 1 country.

Yong ZhuDepartment of Cardiology, Beijing AnZhen Hospital, Capital Medical University.
Maolin ChenDepartment of Emergency, Beijing AnZhen Hospital, Capital Medical University.
Kesen LiuDepartment of Cardiology, Beijing AnZhen Hospital, Capital Medical University.
Ang GaoDepartment of Cardiology, Beijing AnZhen Hospital, Capital Medical University.
Xiangyun KongDepartment of Cardiology, Beijing LuHe Hospital, Capital Medical University.
Yan LiuDepartment of Cardiology, Beijing AnZhen Hospital, Capital Medical University.
Hongya HanDepartment of Cardiology, Beijing AnZhen Hospital, Capital Medical University.
Hong LiDepartment of Cardiology, Beijing AnZhen Hospital, Capital Medical University.
Huagang ZhuDepartment of Cardiology, Beijing AnZhen Hospital, Capital Medical University.
Jianwei ZhangDepartment of Cardiology, Beijing AnZhen Hospital, Capital Medical University.
Yingxin ZhaoDepartment of Cardiology, Beijing AnZhen Hospital, Capital Medical University.
Beijing Anzhen Hospital · CNCapital Medical University · CNBeijing Luhe Hospital Affiliated to Capital Medical University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

aimRecently, the atherogenic index of plasma (AIP) has been proposed as a novel, reliable plasma atherogenicity marker. This study aimed to investigate the association of AIP with the risk of in-stent restenosis (ISR) in patients with acute coronary syndrome (ACS).

methodsThis study retrospectively enrolled patients with ACS followed by angiography within 6 to 18 months after successful percutaneous coronary intervention (PCI) with a drug-eluting stent (DES). And the participants were divided into ISR or non-ISR groups based on the angiographic follow-up results. AIP was defined as the base 10 logarithm of the ratio of serum triglyceride (mmol/L) to high-density lipoprotein cholesterol (mmol/L).

resultsThis study recruited 1319 patients with ACS, 199 of which had ISR. Compared with the non-ISR group, patients in the ISR group had higher level of AIP (0.199±0.290 vs 0.131±0.282, p=0.002). In the multiple logistic regression analysis, AIP was an independent risk factor for DES-ISR (OR=2.100, 95% CI 1.134 to 3.891, p=0.018). When we modulated AIP as a categorical variable, the risk of DES-ISR increased in quartile 4 compared to quartile 1 (OR=1.713, 95% CI 1.040 to 2.822, p=0.034). Furthermore, this association remains stable in various subgroups. Unexpectedly, the subgroup analysis suggested AIP and DES-ISR had a stronger positive association in individuals with low-density lipoprotein cholesterol (LDL-C) <1.8 mmol/L.

conclusionsAIP and the risk of DES-ISR were positively and independently correlated in patients with ACS, especially in those with an LDL-C <1.8 mmol/L.

Indexed as

Acute Coronary SyndromeCoronary RestenosisDrug-Eluting StentsPercutaneous Coronary InterventionCholesterol, LDLCoronary AngiographyHumansRetrospective StudiesRisk FactorsTreatment OutcomeCholesterol, LDLAcute coronary syndromeAtherogenic index of plasmaDrug-eluting stentIn-stent restenosisLow-density lipoprotein cholesterol

Identifiers

PMID34497172
PMCPMC9371759
OpenAlexW3198602309

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.