Evidence map›Paper›PMID 34497144›Full record

ArticleGut2022

Patients with mesenchymal tumours and high

Manuela Salvucci, Nyree Crawford, Katie Stott, Susan Bullman, Daniel B Longley, Jochen H M Prehn

Open access · hybridAbstract read
In one paragraph

Article in Gut, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 45 papers.

0numbers the graph read from it
0cells of the map it votes in
45citing papers in PubMed
3.4field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

45 citing papers in PubMed, 42 citations in OpenAlex.

  1. Article
  2. Review
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  5. Article
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  12. Breast cancer: pathogenesis and treatments.Signal transduction and targeted therapy · 2025
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  14. The rise and evolving role ofCurrent research in microbial sciences · 2025
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  15. Association ofGut microbiome (Cambridge, England) · 2025
    Review
  16. Review
  17. Impact ofFrontiers in immunology · 2025
    Article
  18. Review
  19. Gastro hep advances · 2025
    Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 3 countries.

Manuela SalvucciCentre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland.ORCID 0000-0001-9941-4307
Nyree CrawfordPatrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UK.
Katie StottPatrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UK.
Susan BullmanHuman Biology, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Daniel B LongleyPatrick G Johnston Centre for Cancer Research, School of Medicine, Dentistry and Biomedical Science, Queen's University Belfast, Belfast, UK.
Jochen H M PrehnCentre for Systems Medicine, Department of Physiology and Medical Physics, Royal College of Surgeons in Ireland, Dublin, Ireland jprehn@rcsi.ie.
Queen's University Belfast · GBRoyal College of Surgeons in Ireland · IEFred Hutch Cancer Center · US

Funding

Biotechnology and Biological Sciences Research Council BB/T002824/1Cancer Research UK 24387Medical Research Council G0400302Medical Research Council MC_PC_17117Medical Research Council MR/S021205/1Wellcome Trust 110371/Z/15/Z
6 · The paper itself

Abstract

objectivesTranscriptomic-based subtyping, consensus molecular subtyping (CMS) and colorectal cancer intrinsic subtyping (CRIS) identify a patient subpopulation with mesenchymal traits (CMS4/CRIS-B) and poorer outcome. Here, we investigated the relationship between prevalence of

designWe coupled cell culture experiments with characterisation of

resultsIn vitro,

conclusionThis study identifies CMS4/CRIS-B patients with high

Indexed as

Colorectal NeoplasmsFusobacterium nucleatumHumansInterleukin-8PrevalencePrognosisInterleukin-8biostatisticscolorectal cancerintestinal microbiologymolecular mechanisms

Identifiers

PMID34497144
PMCPMC9279747
OpenAlexW3197148659

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.