ArticleNeurology(R) neuroimmunology & neuroinflammation2021
CSF Chitinase 3-Like 2 Is Associated With Long-term Disability Progression in Patients With Progressive Multiple Sclerosis.
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Article in Neurology(R) neuroimmunology & neuroinflammation, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
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19citing papers in PubMed, 1 pooled it
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Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Comprehensive Meta-Analysis of Differentially Expressed Proteins in Cerebrospinal Fluid Associated with Multiple Sclerosis.International journal of molecular sciences · 2025Pooled it
- Epigenetic Insights in Pediatric Multiple Sclerosis: DNA Methylation Highlights an Involvement of Epstein-Barr Virus Infection and Host Immune Networks.Neurology(R) neuroimmunology & neuroinflammation · 2026Article
- Multi-omics integration and machine learning identify a novel gene signature consisting of CCDC141, CHI3L2, RIMKLB, and PDLIM7 in bronchopulmonary dysplasia associated with neutrophil-driven immune dysregulation.Clinics (Sao Paulo, Brazil) · 2026Article
- Bridging Inflammation and Neurodegeneration in Multiple Sclerosis: Mechanisms and Emerging Therapies.Cureus · 2026Review
- Fluid Biomarkers in Demyelinating Spectrum Disorders: Past, Present, and Prospects.International journal of molecular sciences · 2025Review
- Genetic drivers and clinical consequences of mosaic chromosomal alterations in 1 million individuals.medRxiv : the preprint server for health sciences · 2025Article
- Quantitative proteomics and multi-omics analysis identifies potential biomarkers and the underlying pathological molecular networks in Chinese patients with multiple sclerosis.BMC neurology · 2024Article
- Association of Genetic Markers with the Risk of Early-Onset Breast Cancer in Kazakh Women.Genes · 2024Article
- Article
- CSF levels of Chitinase3like1 correlate with early response to cladribine in multiple sclerosis.Frontiers in immunology · 2024Article
- How Early Is Early Multiple Sclerosis?Journal of clinical medicine · 2023Review
- [15th Post-ECTRIMS Meeting: a review of the latest developments presented at the 2022 ECTRIMS Congress (Part I)].Revista de neurologia · 2023Review
- Demographic and disease-related factors impact on cerebrospinal fluid neurofilament light chain levels in multiple sclerosis.Brain and behavior · 2023Article
- Neurodegeneration and its potential markers in the diagnosing of secondary progressive multiple sclerosis. A review.Frontiers in molecular neuroscience · 2023Review
- Proteomics in Multiple Sclerosis: The Perspective of the Clinician.International journal of molecular sciences · 2022Review
- Emerging Biomarkers of Multiple Sclerosis in the Blood and the CSF: A Focus on Neurofilaments and Therapeutic Considerations.International journal of molecular sciences · 2022Review
- IL-2, IL-6 and chitinase 3-like 2 might predict early relapse activity in multiple sclerosis.PloS one · 2022Article
- CSF TNF and osteopontin levels correlate with the response to dimethyl fumarate in early multiple sclerosis.Therapeutic advances in neurological disorders · 2022Article
- Biological Markers in Early Multiple Sclerosis: the Paved Way for Radiologically Isolated Syndrome.Frontiers in immunology · 2022Review
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Authors and funding
16 authors.
Manuel ComabellaFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain. manuel.comabella@vhir.org.ORCID 0000-0002-2373-6657
Jaume Sastre-GarrigaFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Eva BorrasFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Luisa M VillarFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Albert SaizFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Sergio Martínez-YélamosFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Juan Antonio García-MerinoFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Rucsanda PinteacFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Nicolas FissoloFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Antonio J Sánchez LópezFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Lucienne Costa-FrossardFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Yolanda BlancoFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Sara LlufriuFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Angela Vidal-JordanaFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.ORCID 0000-0002-7270-5507
Eduard SabidóFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.ORCID 0000-0001-6506-7714
Xavier MontalbanFrom the Unitat de Neuroimmunologia Clínica (M.C., J.S.-G., R.P., N.F., A.V.-J., X.M.), Hospital Universitari Vall d´Hebron; Eva Borràs (E.B., E.S.), Proteomics Unit, Universitat Pompeu Fabra, Barcelona; Departments of Neurology and Immunology (L.M.V., L.C.-F.), Hospital Universitario Ramón y Cajal, Instituto Ramón y Cajal de Investigacion Sanitaria, Madrid; Service of Neurology (A.S., Y.B., S.L.), Hospital Clinic and Institut d'Investigacions Biomèdiques August Pi Sunyer, University of Barcelona; Department of Neurology (S.M.-Y.), Bellvitge University Hospital, Barcelona; and Neuroimmunology Unit (J.A.G.M., A.J.S.L.), Hospital Universitario Puerta de Hierro, Madrid, Spain.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveThis study aimed to identify long-term prognostic protein biomarkers associated with disease progression in patients with progressive multiple sclerosis (MS).
methodsCSF samples were collected from a discovery cohort of 28 patients with progressive MS who participated in a clinical trial with interferon beta. Patients were classified into high and low disability progression phenotypes according to numeric progression rates (NPR) and step-based progression rates (SPR) after a mean follow-up time of 12 years. Protein abundance was measured by shotgun proteomics. Selected proteins from the discovery cohort were quantified by parallel reaction monitoring in CSF samples from an independent validation cohort of 41 patients with progressive MS classified also into high and low disability progression phenotypes after a mean follow-up time of 7 years.
resultsOf 2,548 CSF proteins identified in the discovery cohort, 10 were selected for validation based on their association with long-term disability progression: SPATS2-like protein, chitinase 3-like 2 (CHI3L2), plasma serine protease inhibitor, metallothionein-3, phospholipase D4, beta-hexosaminidase, neurexophilin-1, adipocyte enhancer-binding protein 1, cathepsin L1, and lipopolysaccharide-binding protein. Only CHI3L2 was validated, and patients with high disability progression exhibited significantly higher CSF protein levels compared with patients with low disability progression (
conclusionsAlthough further confirmatory studies are needed, we propose CSF CHI3L2 as a prognostic protein biomarker associated with long-term disability progression in patients with progressive MS. CLASSIFICATION OF EVIDENCE: This study provides Class II evidence that high CSF CHI3L2 levels identified higher disability progression in patients with progressive MS.
Indexed as
Disease ProgressionAdultBiomarkersChitinasesFemaleFollow-Up StudiesHumansMaleMiddle AgedMultiple Sclerosis, Chronic ProgressivePatient AcuityPrognosisBiomarkersCHI3L2 protein, humanChitinases
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