Evidence map›Paper›PMID 34497069›Full record

ArticleRNA (New York, N.Y.)2021

Scanning mutagenesis of RNA-binding protein ProQ reveals a quality control role for the Lon protease.

Youssef El Mouali, Falk Ponath, Vinzent Scharrer, Nicolas Wenner, Jay C D Hinton, Jörg Vogel

Open access · hybridAbstract read
In one paragraph

Article in RNA (New York, N.Y.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Article
  3. RNA recognition by minimal ProQ fromRNA (New York, N.Y.) · 2025
    Article
  4. Article
  5. Suppression of theRNA (New York, N.Y.) · 2024
    Article
  6. Article
  7. Article
  8. Article
  9. Article
  10. Article
  11. Review
  12. Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 3 institutions in 2 countries.

Youssef El MoualiInstitute of Molecular Infection Biology (IMIB), University of Würzburg, D-97080 Würzburg, Germany.
Falk PonathHelmholtz Institute for RNA-based Infection Research (HIRI), Helmholtz Centre for Infection Research (HZI), D-97080 Würzburg, Germany.
Vinzent ScharrerInstitute of Molecular Infection Biology (IMIB), University of Würzburg, D-97080 Würzburg, Germany.
Nicolas WennerInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, L7 3EA Liverpool, United Kingdom.
Jay C D HintonInstitute of Infection, Veterinary and Ecological Sciences, University of Liverpool, L7 3EA Liverpool, United Kingdom.
Jörg VogelInstitute of Molecular Infection Biology (IMIB), University of Würzburg, D-97080 Würzburg, Germany.
University of Würzburg · DEUniversity of Liverpool · GBHelmholtz Centre for Infection Research · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The FinO-domain protein ProQ belongs to a widespread family of RNA-binding proteins (RBPs) involved in gene regulation in bacterial chromosomes and mobile elements. While the cellular RNA targets of ProQ have been established in diverse bacteria, the functionally crucial ProQ residues remain to be identified under physiological conditions. Following our discovery that ProQ deficiency alleviates growth suppression of

Indexed as

MutagenesisQuality ControlBacterial ProteinsProtease LaRNA, BacterialRNA-Binding ProteinsSalmonella entericaBacterial ProteinsProtease LaRNA, BacterialRNA-Binding ProteinsHfqLon proteaseProQprotein stabilityRNA-binding proteins

Identifiers

PMID34497069
PMCPMC8594473
OpenAlexW3197107034

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.