Evidence map›Paper›PMID 34497064›Full record

ArticleOpen heart2021

Low-grade metabolic acidosis as a driver of insulin resistance.

James J DiNicolantonio, James H O'Keefe

Abstract readEditorial
In one paragraph

Article in Open heart, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed.

  1. Review
  2. Article
  3. Chronic NHScientific reports · 2026
    Article
  4. Article
  5. Review
  6. Attrition of amino acids in the life span of broiler chickens.Animal nutrition (Zhongguo xu mu shou yi xue hui) · 2025
    Review
  7. Review
  8. Review
  9. Article
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

James J DiNicolantonioDepartment of Preventive Cardiology, Saint Luke's Mid America Heart Institute, Kansas City, Missouri, USA jjdinicol@gmail.com.ORCID 0000-0002-7888-1528
James H O'KeefeUniversity of Missouri-Kansas City, Saint Lukes Mid America Heart Institute, Kansas City, Missouri, USA.ORCID 0000-0002-3376-5822

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

AcidosisFemaleHumansInsulin ResistanceMaleMetabolic SyndromeMiddle Agedatrial fibrillationcoronary artery bypassventricular fibrillation

Identifiers

PMID34497064
PMCPMC8438953

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.