ArticleeLife2021
The corticospinal tract primarily modulates sensory inputs in the mouse lumbar cord.
Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 43 citations in OpenAlex.
- Developmental molecular signatures define de novo cortico-brainstem circuit for skilled forelimb movement.Nature communications · 2026Article
- Mouse sensorimotor cortex reflects complex kinematic details during reaching and grasping.eLife · 2026Article
- Hyperreflexia after corticospinal tract lesion reflects 1 A afferent circuit changes not increased KCC2 hyperexcitability.Experimental neurology · 2025Article
- White matter microstructure abnormalities in children experiencing neglect without other forms of maltreatment.Scientific reports · 2025Article
- Corticospinal Tract Development, Evolution, and Skilled Movements.Movement disorders : official journal of the Movement Disorder Society · 2025Review
- Functional and structural brain remodeling in patients with degenerative cervical myelopathy following cervical decompression surgery.Communications medicine · 2025Article
- The diversity and plasticity of descending motor pathways rewired after stroke and trauma in rodents.Frontiers in neural circuits · 2025Review
- The role of spinal neurons targeted by corticospinal neurons in central poststroke neuropathic pain.CNS neuroscience & therapeutics · 2024Article
- Topographical and cell type-specific connectivity of rostral and caudal forelimb corticospinal neuron populations.Cell reports · 2024Article
- The secondary somatosensory cortex gates mechanical and heat sensitivity.Nature communications · 2024Article
- Anatomical Diversity of the Adult Corticospinal Tract Revealed by Single-Cell Transcriptional Profiling.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023Article
- Locomotor-related propriospinal V3 neurons produce primary afferent depolarization and modulate sensory transmission to motoneurons.Journal of neurophysiology · 2023Article
- Primary somatosensory cortex bidirectionally modulates sensory gain and nociceptive behavior in a layer-specific manner.Nature communications · 2023Article
- The evidence against somatotopic organization of function in the primate corticospinal tract.Brain : a journal of neurology · 2023Review
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- Transmission electron microscopic analysis of myelination in the murine central nervous system.STAR protocols · 2022Article
- Characterization of Spinal Sensorimotor Network Using Transcutaneous Spinal Stimulation during Voluntary Movement Preparation and Performance.Journal of clinical medicine · 2021Article
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Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
It is generally assumed that the main function of the corticospinal tract (CST) is to convey motor commands to bulbar or spinal motoneurons. Yet the CST has also been shown to modulate sensory signals at their entry point in the spinal cord through primary afferent depolarization (PAD). By sequentially investigating different routes of corticofugal pathways through electrophysiological recordings and an intersectional viral strategy, we here demonstrate that motor and sensory modulation commands in mice belong to segregated paths within the CST. Sensory modulation is executed exclusively by the CST via a population of lumbar interneurons located in the deep dorsal horn. In contrast, the cortex conveys the motor command via a relay in the upper spinal cord or supraspinal motor centers. At lumbar level, the main role of the CST is thus the modulation of sensory inputs, which is an essential component of the selective tuning of sensory feedback used to ensure well-coordinated and skilled movement.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.