Evidence map›Paper›PMID 34496924›Full record

ArticleTrials2021

Endoscopic sinus surgery (ESS) to change quality of life for adults with recurrent rhinosinusitis: study protocol for a randomized controlled trial.

Heidi M Kaski, Antti Alakärppä, Ulla Lantto, Aleksi Laajala, Paulus Tokola, Tomi Penna, Pasi Ohtonen, Olli-Pekka Alho

Registry-linked trialOpen access · goldAbstract readClinical Trial Protocol
PubMed Full text at PMC Publisher
In one paragraph

Article in Trials, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04241016 (A Randomised Controlled Study of Endoscopic Sinus Surgery for Recurrent Acute Rhinosinusitis), which is not on this map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.8field-weighted citation impact, top 29% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04241016 naunknown statusnot on this map

A Randomised Controlled Study of Endoscopic Sinus Surgery for Recurrent Acute Rhinosinusitis

TypeinterventionalSponsorOulu University HospitalRan2020 to 2025Enrolled80ConditionsMaxillary Sinusitis, Sinusitis, Acute, SinusitisArmsEndoscopic sinus surgery (ESS)
3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 1 country.

Heidi M KaskiDepartment of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, P.O. Box 5000, FIN-90014, Oulu, Finland. heidi.kaski@student.oulu.fi.ORCID http://orcid.org/0000-0003-2109-9356
Antti AlakärppäDepartment of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, P.O. Box 5000, FIN-90014, Oulu, Finland.
Ulla LanttoDepartment of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, P.O. Box 5000, FIN-90014, Oulu, Finland.
Aleksi LaajalaDepartment of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, P.O. Box 5000, FIN-90014, Oulu, Finland.
Paulus TokolaDepartment of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, P.O. Box 5000, FIN-90014, Oulu, Finland.
Tomi PennaDepartment of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, P.O. Box 5000, FIN-90014, Oulu, Finland.
Pasi OhtonenMedical Research Center Oulu, Oulu, Finland.
Olli-Pekka AlhoDepartment of Otorhinolaryngology and Head and Neck Surgery, Oulu University Hospital, P.O. Box 5000, FIN-90014, Oulu, Finland.
Oulu University Hospital · FI

Funding

Oulun Yliopisto 18 999 €
6 · The paper itself

Abstract

backgroundEndoscopic sinus surgery (ESS) has been used for decades to treat recurrent acute rhinosinusitis episodes (RARS) in adults. RARS results in infectious symptoms, antibiotic courses, sick leaves, and impaired quality of life. Theoretically, the ESS procedure, through improving the drainage of the paranasal sinuses, decreases the symptoms and enhances the quality of life of the RARS patients. Whether this is true has not been reported in a randomized trial yet.

methodsWe conduct a single-center, non-blinded, randomized, 6-month, parallel group superiority clinical study including 80 adult participants referred to surgical treatment for RARS. The participants will either have ESS or conservative medical treatment (control group). The primary outcome will be the difference between the mean disease-specific Sinonasal Outcome Test 22 (quality of life questionnaire) change scores (from baseline to 6 months) of ESS and control group. DISCUSSION: This study will add significant new information to the effect and harms of ESS procedure in the treatment of adults with RARS.

trial registrationClinicalTrials.gov NCT04241016 . Registered on 17 January 2020.

Indexed as

Paranasal SinusesRhinitisSinusitisAdultChronic DiseaseEndoscopyEquivalence Trials as TopicHumansQuality of LifeRandomized Controlled Trials as TopicTreatment OutcomeEndoscopic sinus surgeryQuality of lifeRandomized controlled trialRecurrent rhinosinusitisRhinosinusitisTreatment

Identifiers

PMID34496924
PMCPMC8424164
OpenAlexW3197812397

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.