ArticleParticle and fibre toxicology2021
Prospects on the nano-plastic particles internalization and induction of cellular response in human keratinocytes.
Article in Particle and fibre toxicology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed, 96 citations in OpenAlex.
- Effects of micro- and nano-plastics exposure on cellular senescence: an overview.Archives of toxicology · 2026Review
- Environmental Exposure to Micro- and Nanoplastics: Linking Cardiovascular Disease and Cancer Through Shared Biological Pathways-A Critical Review.Antioxidants (Basel, Switzerland) · 2026Review
- Pulmonary toxicity of micro- and nano polyethylene particles following intratracheal instillation in rats.Particle and fibre toxicology · 2026Article
- The Particle Size Effect: Cytotoxicity and Cellular Uptake of Polystyrene Nanoplastics in Human Keratinocytes.Toxics · 2026Article
- Microplastics and Nanoplastics in Cardiovascular Disease: An Emerging Cardiovascular Risk Factor.Cardiovascular toxicology · 2026Review
- Polyethylene nano- and microplastics trigger metabolic stress responses in human vaginal epithelial cells.Cell death discovery · 2026Article
- Emerging cardiovascular risks of micro- and nanoplastics: toxic effects and mechanistic pathways.Particle and fibre toxicology · 2026Review
- Emerging mechanisms of microplastic-induced skin diseases: a perspective from the gut-skin axis.Journal of translational medicine · 2026Review
- [Microplastic and skin-an update].Dermatologie (Heidelberg, Germany) · 2026Review
- Organ-specific apoptotic pathways induced by micro- and nanoplastics: a systematic review ofFrontiers in toxicology · 2026Review
- Polystyrene Nanoplastics in Human Gastrointestinal Models-Cellular and Molecular Mechanisms of Toxicity.International journal of molecular sciences · 2025Review
- Plastics in dermatology: A review and solutions.Journal of the European Academy of Dermatology and Venereology : JEADV · 2025Review
- Article
- Review
- Environmental protein corona on nanoplastics altered the responses of skin keratinocytes and fibroblast cells to the particles.Journal of hazardous materials · 2025Article
- Risk Assessment of Microplastics in Humans: Distribution, Exposure, and Toxicological Effects.Polymers · 2025Review
- Interaction of Polystyrene Nanoplastic with Lipid Membranes.The journal of physical chemistry. B · 2025Article
- Interaction of Polystyrene Nanoplastics with Biomolecules and Environmental Pollutants: Effects on Human Hepatocytes.International journal of molecular sciences · 2025Article
- The Impact of Microplastics in Food and Drugs on Human Health: A Review of the MENA Region.International journal of environmental research and public health · 2025Review
- Artificial plasticenta: how polystyrene nanoplastics affectFrontiers in cell and developmental biology · 2025Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundToday, cosmetic products are very popular with both men and women to improve their appearance and increase their social acceptability.
resultsIn this study, nano-sized (30-300 nm) plastic particles were isolated from the commercial face-scrubs and treated on the human keratinocytes. The observed adherence of polyethylene nano-plastics (PENPs), polystyrene NPs (PSNPs), and face-scrubs isolated nano-plastics (NPs) on the keratin layer reveals a significant attachment of NPs from the cosmetics that are applied on the skin for a short duration. This attachment property could facilitate further adherence of protein molecules on NPs and the protein-corona formation. The protein-corona mimics protein aggregates, thereby triggers macropinocytosis, followed by the macropinolysosomal process in the cell. These internalized NPs induced the concentration-dependent cytotoxic, cytostatic and cytoprotective activity in keratinocytes. Both single dose and chronic long-term exposure of lethal and sub-lethal concentrations of NPs resulted in oxidative stress-mediated down-regulation of cell growth and proliferation inhibition. Autophagic structures and premature aging were also observed using an electron microscopy and a senescence marker, respectively in the NPs internalized HaCaT cells incubated in a fresh, NPs-free medium.
conclusionThough 2D culture models have many limitations, it produces significant conceptual advancements. This work provides an insight into the NPs concentration-dependent regulatory, cytoprotective, and cytotoxic effects in HaCaT cells. However, 3D model studies are required to identify the detailed mechanisms of NPs toxicity and cytoprotective events in cells at the molecular level.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.