Evidence map›Paper›PMID 34496903›Full record

ArticleVirology journal2021

In vitro efficacy of Artemisia extracts against SARS-CoV-2.

Chuanxiong Nie, Jakob Trimpert, Sooyeon Moon, Rainer Haag, Kerry Gilmore, Benedikt B Kaufer, Peter H Seeberger

Open access · goldAbstract read
In one paragraph

Article in Virology journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers.

0numbers the graph read from it
0cells of the map it votes in
32citing papers in PubMed
10.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

32 citing papers in PubMed, 71 citations in OpenAlex.

  1. Identification of potential SARS-CoV-2 MJournal of computer-aided molecular design · 2026
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  2. Potential ofPharmaceuticals (Basel, Switzerland) · 2025
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  4. Profiling of sesquiterpenoid fractions fromBiomolecules & biomedicine · 2025
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  11. Five DifferentInternational journal of molecular sciences · 2023
    Article
  12. Artemisinin as a therapeuticNatural product reports · 2023
    Review
  13. Article
  14. The mint versus Covid hypothesis.Medical hypotheses · 2023
    Article
  15. Pathogens (Basel, Switzerland) · 2023
    Article
  16. Article
  17. Article
  18. Antiviral activity of medicinal plant-derived products against SARS-CoV-2.Experimental biology and medicine (Maywood, N.J.) · 2022
    Review
  19. Market Women's Perspectives on Coronavirus Disease 2019 (COVID-19): The Case of Ghana and South Africa.International journal of environmental research and public health · 2022
    Article
  20. SARS-CoV-2 omicron variants succumbbioRxiv : the preprint server for biology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 3 institutions in 2 countries.

Chuanxiong NieInstitute for Virology, Freie Universität Berlin, Robert von Ostertag-Str. 7-13, 14163, Berlin, Germany.
Jakob TrimpertInstitute for Virology, Freie Universität Berlin, Robert von Ostertag-Str. 7-13, 14163, Berlin, Germany.
Sooyeon MoonDepartment for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam, Germany.
Rainer HaagDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.
Kerry GilmoreDepartment for Biomolecular Systems, Max-Planck Institute for Colloids and Interfaces, Am Mühlenberg 1, 14476, Potsdam, Germany.
Benedikt B KauferInstitute for Virology, Freie Universität Berlin, Robert von Ostertag-Str. 7-13, 14163, Berlin, Germany. Benedikt.Kaufer@fu-berlin.de.
Peter H SeebergerDepartment of Chemistry and Biochemistry, Freie Universität Berlin, Takustrasse 3, 14195, Berlin, Germany.ORCID 0000-0003-3394-8466
Freie Universität Berlin · DEMax Planck Institute of Colloids and Interfaces · DEUniversity of Connecticut · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTraditional medicines based on herbal extracts have been proposed as affordable treatments for patients suffering from coronavirus disease 2019 (COVID-19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Teas and drinks containing extracts of Artemisia annua and Artemisia afra have been widely used in Africa in efforts to prevent SARS-CoV-2 infection and fight COVID-19.

methodsThe plant extracts and Covid-Organics drink produced in Madagascar were tested for plaque reduction using both feline coronavirus and SARS-CoV-2 in vitro. Their cytotoxicities were also investigated.

resultsSeveral extracts as well as Covid-Organics inhibited SARS-CoV-2 and FCoV infection at concentrations that did not affect cell viability.

conclusionsSome plant extracts show inhibitory activity against FCoV and SARS-CoV-2. However, it remains unclear whether peak plasma concentrations in humans can reach levels needed to inhibit viral infection following consumption of teas or Covid-Organics. Clinical studies are required to evaluate the utility of these drinks for COVID-19 prevention or treatment of patients.

Indexed as

AnimalsAntiviral AgentsArtemisiaCell LineCell SurvivalCoronavirus, FelinePlant ExtractsSARS-CoV-2Viral Plaque AssayAntiviral AgentsPlant ExtractsAntiviralsArtemisia afraArtemisia annuaCOVID-19Covid-organicsFeline coronavirus (FCoV)SARS-CoV-2

Identifiers

PMID34496903
PMCPMC8424155
OpenAlexW3198873669

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.