Evidence map›Paper›PMID 34496845›Full record

SynthesisBMC medicine2021

Tuberculosis related disability: a systematic review and meta-analysis.

Kefyalew Addis Alene, Kinley Wangdi, Samantha Colquhoun, Kudakwashe Chani, Tauhid Islam, Kalpeshsinh Rahevar, Fukushi Morishita, Anthony Byrne, Justin Clark, Kerri Viney

Abstract readMeta-AnalysisSystematic Review
In one paragraph

Synthesis in BMC medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 61 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
61citing papers in PubMed, 3 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

61 citing papers in PubMed, 3 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Review
  5. Article
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  10. Review
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  14. Post-tuberculosis lung disease.Breathe (Sheffield, England) · 2026
    Review
  15. Article
  16. Review
  17. Article
  18. Observational
  19. Article
  20. Article

1 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Kefyalew Addis Alene *Faculty of Health Sciences, Curtin University, Kent St, Bentley, Perth, 6102, Western Australia, Australia.
Kinley Wangdi *Research School of Population Health, The Australian National University, 62 Mills Road, Acton, Canberra, ACT, 2601, Australia.
Samantha ColquhounResearch School of Population Health, The Australian National University, 62 Mills Road, Acton, Canberra, ACT, 2601, Australia. samantha.colquhoun@anu.edu.au.
Kudakwashe ChaniResearch School of Population Health, The Australian National University, 62 Mills Road, Acton, Canberra, ACT, 2601, Australia.
Tauhid IslamWorld Health Organization (WHO) Regional Office for the Western Pacific, The Philippines, Manila, Philippines.
Kalpeshsinh RahevarWorld Health Organization (WHO) Regional Office for the Western Pacific, The Philippines, Manila, Philippines.
Fukushi MorishitaWorld Health Organization (WHO) Regional Office for the Western Pacific, The Philippines, Manila, Philippines.
Anthony ByrneSt Vincent's Hospital, Sydney, 406 Victoria St, Darlinghurst, Sydney, 2010, New South Wales, Australia.
Justin ClarkInstitute for Evidence-Based Healthcare, Bond University, 14 University Drive, Robina, 4266, Queensland, Australia.
Kerri VineyResearch School of Population Health, The Australian National University, 62 Mills Road, Acton, Canberra, ACT, 2601, Australia.

Funding

World Health Organization 001
6 · The paper itself

Abstract

backgroundThe sustainable development goals aim to improve health for all by 2030. They incorporate ambitious goals regarding tuberculosis (TB), which may be a significant cause of disability, yet to be quantified. Therefore, we aimed to quantify the prevalence and types of TB-related disabilities.

methodsWe performed a systematic review of TB-related disabilities. The pooled prevalence of disabilities was calculated using the inverse variance heterogeneity model. The maps of the proportions of common types of disabilities by country income level were created.

resultsWe included a total of 131 studies (217,475 patients) that were conducted in 49 countries. The most common type of disabilities were mental health disorders (23.1%), respiratory impairment (20.7%), musculoskeletal impairment (17.1%), hearing impairment (14.5%), visual impairment (9.8%), renal impairment (5.7%), and neurological impairment (1.6%). The prevalence of respiratory impairment (61.2%) and mental health disorders (42.0%) was highest in low-income countries while neurological impairment was highest in lower middle-income countries (25.6%). Drug-resistant TB was associated with respiratory (58.7%), neurological (37.2%), and hearing impairments (25.0%) and mental health disorders (26.0%), respectively.

conclusionsTB-related disabilities were frequently reported. More uniform reporting tools for TB-related disability and further research to better quantify and mitigate it are urgently needed. PROSPERO REGISTRATION NUMBER: CRD42019147488.

Indexed as

Mental DisordersPersons with DisabilitiesTuberculosisTuberculosis, Multidrug-ResistantHumansPrevalenceDisabilityImpairmentMeta-analysisTreatmentTuberculosis

Identifiers

PMID34496845
PMCPMC8426113

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.