Evidence map›Paper›PMID 34496825›Full record

ArticleBMC public health2021

Impact of experienced HIV stigma on health is mediated by internalized stigma and depression: results from the people living with HIV stigma index in Ontario.

Jason M Lo Hog Tian, James R Watson, Francisco Ibáñez-Carrasco, Billy Tran, Janet A Parsons, Robert G Maunder, Kiffer G Card, Stefan Baral, Christian Hui, Anthony R Boni and 4 more

Abstract read
In one paragraph

Article in BMC public health, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Jason M Lo Hog TianMAP Centre for Urban Health Solutions, Unity Health Toronto, Toronto, Canada.
James R WatsonMAP Centre for Urban Health Solutions, Unity Health Toronto, Toronto, Canada.
Francisco Ibáñez-CarrascoDalla Lana School of Public Health, University of Toronto, Toronto, Canada.
Billy TranMAP Centre for Urban Health Solutions, Unity Health Toronto, Toronto, Canada.
Janet A ParsonsLi Ka Shing Knowledge Institute, Unity Health Toronto, Toronto, Canada.
Robert G MaunderSinai Health System, University of Toronto, Toronto, Canada.
Kiffer G CardSchool of Public Health and Social Policy, University of Victoria, Victoria, Canada.
Stefan BaralDepartment of Epidemiology, Johns Hopkins School of Public Health, Baltimore, USA.
Christian HuiCanadian HIV Stigma Index Steering Committee, Toronto, Canada.
Anthony R BoniMAP Centre for Urban Health Solutions, Unity Health Toronto, Toronto, Canada.
Monisola AjiboyeMAP Centre for Urban Health Solutions, Unity Health Toronto, Toronto, Canada.
Joanne D LindsayMAP Centre for Urban Health Solutions, Unity Health Toronto, Toronto, Canada.
Sean B RourkeMAP Centre for Urban Health Solutions, Unity Health Toronto, Toronto, Canada. sean.rourke@utoronto.ca.ORCID 0000-0001-6162-7358
Ontario HIV Stigma Index Team

Funding

CIHR FRN 151186CIHR FRN 165644
6 · The paper itself

Abstract

backgroundExperiences of HIV stigma remain prevalent across Canada, causing significant stress and negatively affecting the health and wellbeing of people living with HIV. While studies have consistently demonstrated that stigma negatively impacts health, there has been limited research on the mechanisms behind these effects. This study aims to identify which dimensions of stigma have significant relationships with self-rated health and examine the mechanisms by which those types of stigma impact self-rated health.

methodsWe recruited 724 participants to complete the People Living with HIV Stigma Index in Ontario, designed by people living with HIV to measure nuanced changes in stigma and discrimination. The present study utilizes data from externally validated measures of stigma and health risks that were included in the survey. First, we conducted multiple regression analyses to examine which variables had a significant impact on self-rated health. Results from the multiple regression guided the mediation analysis. A parallel mediation model was created with enacted stigma as the antecedent, internalized stigma and depression as the mediators, and self-rated health as the outcome.

resultsIn the multiple regression analysis, internalized stigma (coefficient = -0.20, p < 0.01) and depression (coefficient = -0.07, p < 0.01) were both significant and independent predictors of health. Mediation analyses demonstrated that the relationship between enacted stigma and self-rated health is mediated in parallel by both internalized stigma [coefficient = -0.08, se = 0.03, 95% CI (-0.14, -0.02)] and depression [coefficient = -0.16, se = 0.03, 95% CI (-0.22, -0.11)].

conclusionsWe developed a mediation model to explain how HIV-related stigma negatively impacts health. We found that that enacted stigma, or experiences of prejudice or discrimination, can lead to internalized stigma, or internalization of negative thoughts regarding one's HIV status and/or increased depressive symptoms which then may lead to worse overall health. Highlighting the importance of internalized stigma and depression has the potential to shape the development of targeted intervention strategies aimed at reducing the burden of stigma and improving the health and wellbeing of people living with HIV.

Indexed as

DepressionHIV InfectionsHumansOntarioPrejudiceSocial StigmaDepressionHIVMediationRegressionSelf-rated healthStigma

Identifiers

PMID34496825
PMCPMC8427956

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.