ReviewBMC pediatrics2021
Vitamin K prophylaxis in newborns.
Review in BMC pediatrics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
15 citing papers in PubMed, 47 citations in OpenAlex.
- Vitamin K Biochemistry and Pharmacokinetics: The Basis of Late Vitamin K Deficiency Intracranial Bleeding in Early Infancy.International journal of molecular sciences · 2026Review
- Vitamin K Prophylaxis in Newborns: A Narrative Review of the Molecular Basis, Clinical Evidence, and Comparative Effectiveness of Intramuscular Versus Oral Administration and Parental Hesitation.International journal of molecular sciences · 2026Review
- Oral neonatal vitamin K deficiency bleeding prophylaxis in Switzerland (2018-2024), still valid guidelines for healthy infants.European journal of pediatrics · 2026Article
- Vitamin K deficiency bleeding in children with cholestatic liver disease: a systematic review and meta-analysis.Research and practice in thrombosis and haemostasis · 2025Review
- Characterizing Vitamin K Refusal in Term Hospital-Born Infants in Minnesota, 2015-2019.Hospital pediatrics · 2025Article
- Article
- Vitamin K prophylaxis in neonates: comparing two different oral regimens.Journal of perinatology : official journal of the California Perinatal Association · 2024Article
- Late-onset vitamin K deficiency presenting as haemorrhagic shock and severe multi-system organ failure.BMJ case reports · 2024Article
- Beyond the Coagulation Cascade: Vitamin K and Its Multifaceted Impact on Human and Domesticated Animal Health.Current issues in molecular biology · 2024Review
- Article
- Intrauterine fetal death due to fetal intracranial hemorrhage associated with maternal vitamin K deficiency: A case report.Case reports in women's health · 2023Article
- Effectiveness of early essential newborn care implementation in four counties of western China.BMC health services research · 2022Article
- Vitamin K shot in newborn babies: An unprecedented sequelae.Annals of medicine and surgery (2012) · 2022Article
- Physicians' Opinion and Practice of Vitamin K Administration at Birth in Romania.Healthcare (Basel, Switzerland) · 2022Article
- Primary health care for children - evidence for prevention.BMC pediatrics · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We looked at existing recommendations and supporting evidence on the effectiveness of vitamin K given after birth in preventing the haemorrhagic disease of the newborn (HDN).We conducted a literature search up to the 10th of December 2019 by using key terms and manual search in selected sources. We summarized the recommendations and the strength of the recommendation when and as reported by the authors. We summarized the main findings of systematic reviews with the certainty of the evidence as reported.All newborns should receive vitamin K prophylaxis, as it has been proven that oral and intramuscular prophylactic vitamin K given after birth are effective for preventing classical HDN. There are no randomized trials looking at the efficacy of vitamin K supplement on late HDN. There are no randomized trials comparing the oral and intramuscular route of administration of prophylactic vitamin K in newborns. From older trials and surveillance data, it seems that there is no significant difference between the intramuscular and the oral regimens for preventing classical and late HDN, provided that the oral regimen is duly completed. Evidence assessing vitamin K prophylaxis in preterm infants is scarce.
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.