Evidence map›Paper›PMID 34496615›Full record

ArticleStroke2021

Factors Associated With Decreased Accuracy of Modified Thrombolysis in Cerebral Infarct Scoring Among Neurointerventionalists During Thrombectomy.

Elliot Pressman, Muhammad Waqas, Victoria Sands, Adnan Siddiqui, Kenneth Snyder, Jason Davies, Elad Levy, Ciprian Ionita, Waldo Guerrero, Zeguang Ren and 1 more

Open access · bronzeAbstract read
In one paragraph

Article in Stroke, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.9field-weighted citation impact, top 25% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 10 citations in OpenAlex.

  1. Article
  2. Trends in device utilization and procedural outcomes of endovascular treatment of acute ischemic stroke: A 10-year review of individual institutional experience.Interventional neuroradiology : journal of peritherapeutic neuroradiology, surgical procedures and related neurosciences · 2025
    Article
  3. Article
  4. Efficacy and safety of spot heating and ultrasound irradiation on in vitro and in vivo thrombolysis models.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 2 institutions in 1 country.

Elliot PressmanDepartment of Neurosurgery, University of South Florida, Tampa (E.P., V.S., W.G., Z.R., M.M.).ORCID 0000-0002-5160-802X
Muhammad WaqasDepartment of Neurosurgery, University at Buffalo, NY (M.W., A.S., K.S., J.D., E.L., C.I.).ORCID 0000-0003-4500-7954
Victoria SandsDepartment of Neurosurgery, University of South Florida, Tampa (E.P., V.S., W.G., Z.R., M.M.).
Adnan SiddiquiDepartment of Neurosurgery, University at Buffalo, NY (M.W., A.S., K.S., J.D., E.L., C.I.).ORCID 0000-0002-9519-0059
Kenneth SnyderDepartment of Neurosurgery, University at Buffalo, NY (M.W., A.S., K.S., J.D., E.L., C.I.).
Jason DaviesDepartment of Neurosurgery, University at Buffalo, NY (M.W., A.S., K.S., J.D., E.L., C.I.).
Elad LevyDepartment of Neurosurgery, University at Buffalo, NY (M.W., A.S., K.S., J.D., E.L., C.I.).ORCID 0000-0002-6208-3724
Ciprian IonitaDepartment of Neurosurgery, University at Buffalo, NY (M.W., A.S., K.S., J.D., E.L., C.I.).
Waldo GuerreroDepartment of Neurosurgery, University of South Florida, Tampa (E.P., V.S., W.G., Z.R., M.M.).ORCID 0000-0002-4781-3944
Zeguang RenDepartment of Neurosurgery, University of South Florida, Tampa (E.P., V.S., W.G., Z.R., M.M.).ORCID 0000-0002-7431-2643
Maxim MokinDepartment of Neurosurgery, University of South Florida, Tampa (E.P., V.S., W.G., Z.R., M.M.).ORCID 0000-0003-4270-8667
University at Buffalo, State University of New York · USUniversity of South Florida · US

Funding

Optimizing Approaches to Endovascular Therapy of Acute Ischemic StrokeR21NS109575 · NINDS · UNIVERSITY OF SOUTH FLORIDA · PI MOKIN, MAXIM · 2019 to 2019
$420k
NINDS NIH HHS R21 NS109575
6 · The paper itself

Abstract

Background and Purpose: The modified Thrombolysis in Cerebral Infarct (mTICI) score is used to grade angiographic outcome after endovascular thrombectomy. We sought to identify factors that decrease the accuracy of intraprocedural mTICI. Methods: We performed a 2-center retrospective cohort study comparing operator (n=6) mTICI scores to consensus scores from blinded adjudicators. Groups were also assessed by dichotomizing mTICI scores to 0–2a versus 2b–3. Results: One hundred thirty endovascular thrombectomy procedures were included. Operators and adjudicators had a pairwise agreement in 96 cases (73.8%). Krippendorff α was 0.712. Multivariate analysis showed endovascular thrombectomy overnight (odds ratio [OR]=3.84 [95% CI, 1.22–12.1]), lacking frontal (OR, 5.66 [95 CI, 1.36–23.6]), or occipital (OR, 7.18 [95 CI, 2.12–24.3]) region reperfusion, and higher operator mTICI scores (OR, 2.16 [95 CI, 1.16–4.01]) were predictive of incorrectly scoring mTICI intraprocedurally. With dichotomized mTICI scores, increasing number of passes was associated with increased risk of operator error (OR, 1.93 [95 CI, 1.22–3.05]). Conclusions: In our study, mTICI disagreement between operator and adjudicators was observed in 26.2% of cases. Interventions that took place between 22:30 and 4:00, featured frontal or occipital region nonperfusion, higher operator mTICI scores, and increased number of passes had higher odds of intraprocedural mTICI inaccuracy.

Indexed as

Treatment OutcomeAgedAngiography, Digital SubtractionCerebral InfarctionCohort StudiesEndovascular ProceduresFemaleHumansMaleMiddle AgedRetrospective StudiesThrombectomyangiographyconsensusodds ratioreperfusionthrombectomy

Identifiers

PMID34496615
PMCPMC8650713
OpenAlexW3196660640

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.