ReviewJournal of the American Heart Association2021
Clinical Implications for Exercise at Altitude Among Individuals With Cardiovascular Disease: A Scientific Statement From the American Heart Association.
Review in Journal of the American Heart Association, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to 2 registered trials, which are not on this map. Cited by 29 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Impact of Hypoxia on Resting and Exertional Right Ventricular Performance - A PILOT STUDY
Impact of Iron Supplementation on Right Ventricular Function and Exercise Performance in Hypoxia (A Sub-Study)
Who cites it
29 citing papers in PubMed.
- The Effect of a Single Bout of Exercise to Volitional Exhaustion Under Moderate Normobaric Hypoxia on the Kinetics of Cardiac Biomarkers in Trained and Untrained Men.International journal of molecular sciences · 2026Article
- Residence at 1200 m Induces a Threefold Reduction in the Risk of Acute Mountain Sickness After Rapid Ascent to 3600 m.Medicine and science in sports and exercise · 2026Article
- Short-Term High-Altitude Exposure Alters Pharyngeal and Gut Microbiome.Environment & health (Washington, D.C.) · 2026Article
- Cardiovascular Exercise Physiology Under Hypoxia, Microgravity, and Heat Stress: A Review with Public Health Implications.International journal of environmental research and public health · 2026Review
- Association between baseline blood pressure variability and cardiac mechanics and electrophysiology after acute exposure to high altitude.BMC cardiovascular disorders · 2026Article
- Exercise in acute and subacute hypoxic conditions: physiological responses affecting oxygen delivery and their applications to human health.The Journal of physiology · 2026Review
- Pre-ascent hypoxic preparedness for rapid-ascent mountain sports: translating military evidence into civilian acclimatization research.Frontiers in physiology · 2026Article
- Integrated proteomics and metabolomics reveal mechanisms of blood pressure reduction in spontaneously hypertensive rats under hypoxic conditions.Frontiers in physiology · 2026Article
- High altitude pulmonary hypertension: overlap with other types of pulmonary hypertension and implications for treatment.BMJ medicine · 2026Review
- Patients' perspectives on pulmonary rehabilitation for pulmonary hypertension in high-altitude areas: a mixed-methods study.Frontiers in public health · 2026Article
- Cerebral, Muscle and Blood Oxygenation in Patients with Pulmonary Vascular Disease Whilst Breathing Normobaric Hypoxia vs. Normoxia Before and After Sildenafil: Data from a Randomised Controlled Trial.Journal of clinical medicine · 2025Article
- Health-Related Physical Fitness Associated With Hypertension Risk in Adults Living in Sub-Plateau Environments.Journal of clinical hypertension (Greenwich, Conn.) · 2025Article
- Acute Hypoxic Exposure and Right Ventricular Adaptation: Morphological Remodeling, Functional Dynamics, and Hemodynamic Implications in Healthy Individuals.Physiological research · 2025Review
- Human adaptation to high altitude: acclimatization and reversibility of haemodynamics.National science review · 2025Article
- Are Suggested Hiking Times Accurate? A Validation of Hiking Time Estimations for Preventive Measures in Mountains.Medicina (Kaunas, Lithuania) · 2025Article
- Review
- Association of altitude with all-cause and cardiovascular mortality among patients with hypertension: a cohort study in Southwest China.BMC public health · 2024Article
- Article
- Effect of menstrual cycle phase on physiological responses in healthy women at rest and during submaximal exercise at high altitude.Scientific reports · 2024Article
- Right ventricular performance during acute hypoxic exercise.The Journal of physiology · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
An increasing number of individuals travel to mountainous environments for work and pleasure. However, oxygen availability declines at altitude, and hypoxic environments place unique stressors on the cardiovascular system. These stressors may be exacerbated by exercise at altitude, because exercise increases oxygen demand in an environment that is already relatively oxygen deplete compared with sea-level conditions. Furthermore, the prevalence of cardiovascular disease, as well as diseases such as hypertension, heart failure, and lung disease, is high among individuals living in the United States. As such, patients who are at risk of or who have established cardiovascular disease may be at an increased risk of adverse events when sojourning to these mountainous locations. However, these risks may be minimized by appropriate pretravel assessments and planning through shared decision-making between patients and their managing clinicians. This American Heart Association scientific statement provides a concise, yet comprehensive overview of the physiologic responses to exercise in hypoxic locations, as well as important considerations for minimizing the risk of adverse cardiovascular events during mountainous excursions.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.