ArticleCell reports2021
Distance-tuned neurons drive specialized path integration calculations in medial entorhinal cortex.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Spatial and temporal representations are organized along a stable coding gradient in the medial entorhinal cortex.bioRxiv : the preprint server for biology · 2026Article
- Grid maps are disrupted after large-scale arena expansion and recover with experience.Nature communications · 2026Article
- Gaussian Process Inference Reveals Non-separability of Position and Velocity Tuning in Grid Cells.bioRxiv : the preprint server for biology · 2026Article
- Aberrant medial entorhinal cortex dynamics link tau pathology to spatial memory impairment.bioRxiv : the preprint server for biology · 2026Article
- Theta Activity Supports Landmark-Based Correction of Naturalistic Human Path Integration.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Environmental Novelty Modulates Rapid Cortical Plasticity During Navigation.bioRxiv : the preprint server for biology · 2025Article
- Spatial coding dysfunction and network instability in the aging medial entorhinal cortex.Nature communications · 2025Article
- Distinct brain regions map olfactory and visual spaces.bioRxiv : the preprint server for biology · 2025Article
- Article
- Hexagons all the way down: grid cells as a conformal isometric map of space.PLoS computational biology · 2025Article
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- Medial entorhinal cortex mediates learning of context-dependent interval timing behavior.Nature neuroscience · 2024Article
- Article
- Uncovering 2-D toroidal representations in grid cell ensemble activity during 1-D behavior.Nature communications · 2024Article
- Variable recruitment of distal tuft dendrites shapes new hippocampal place fields.bioRxiv : the preprint server for biology · 2024Article
- Mental navigation in the primate entorhinal cortex.Nature · 2024Article
- A consistent map in the medial entorhinal cortex supports spatial memory.Nature communications · 2024Article
- Article
- Coherently remapping toroidal cells but not Grid cells are responsible for path integration in virtual agents.iScience · 2023Article
- Hippocampal firing fields anchored to a moving object predict homing direction during path-integration-based behavior.Nature communications · 2023Article
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5 authors.
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Abstract
During navigation, animals estimate their position using path integration and landmarks, engaging many brain areas. Whether these areas follow specialized or universal cue integration principles remains incompletely understood. We combine electrophysiology with virtual reality to quantify cue integration across thousands of neurons in three navigation-relevant areas: primary visual cortex (V1), retrosplenial cortex (RSC), and medial entorhinal cortex (MEC). Compared with V1 and RSC, path integration influences position estimates more in MEC, and conflicts between path integration and landmarks trigger remapping more readily. Whereas MEC codes position prospectively, V1 codes position retrospectively, and RSC is intermediate between the two. Lowered visual contrast increases the influence of path integration on position estimates only in MEC. These properties are most pronounced in a population of MEC neurons, overlapping with grid cells, tuned to distance run in darkness. These results demonstrate the specialized role that path integration plays in MEC compared with other navigation-relevant cortical areas.
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