Evidence map›Paper›PMID 34496247›Full record

ArticleCell reports2021

Negative charge in the RACK1 loop broadens the translational capacity of the human ribosome.

Madeline G Rollins, Manidip Shasmal, Nathan Meade, Helen Astar, Peter S Shen, Derek Walsh

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 22 citations in OpenAlex.

  1. Structural basis for emetine inhibition of ribosome translocation inbioRxiv : the preprint server for biology · 2026
    Article
  2. Article
  3. Review
  4. Review
  5. Article
  6. Impacts of ribosomal RNA sequence variation on gene expression and phenotype.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 2025
    Review
  7. Article
  8. Article
  9. Article
  10. Review
  11. Article
  12. Specialized Ribosomes in Health and Disease.International journal of molecular sciences · 2023
    Review
  13. Ribosomes in poxvirus infection.Current opinion in virology · 2022
    Review
  14. Article
  15. Review
  16. Review
  17. Review
  18. Ribosomal control in RNA virus-infected cells.Frontiers in microbiology · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Madeline G RollinsDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Manidip ShasmalDepartment of Biochemistry, School of Medicine, University of Utah, Salt Lake City, UT 84112, USA.
Nathan MeadeDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Helen AstarDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA.
Peter S ShenDepartment of Biochemistry, School of Medicine, University of Utah, Salt Lake City, UT 84112, USA. Electronic address: peter.shen@biochem.utah.edu.
Derek WalshDepartment of Microbiology-Immunology, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611, USA. Electronic address: derek.walsh@northwestern.edu.
Northwestern University · USUniversity of Utah · US

Funding

Poxvirus manipulation of the host cell protein synthesis machineryR01AI127456 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI Peter Shen, Derek Walsh · 2017 to 2026
$4.4M
Visualizing the Mechanisms of Protein Quality ControlR35GM133772 · NIGMS · UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH · PI Peter Shen · 2019 to 2026
$3.4M
RACK1-mediated control of mRNA selectivity by poxvirusesF31AI152548 · NIAID · NORTHWESTERN UNIVERSITY AT CHICAGO · PI ROLLINS, MADELINE GRACE · 2020 to 2021
$74k
NIAID NIH HHS F31 AI152548NIAID NIH HHS R01 AI127456NIGMS NIH HHS R35 GM133772
6 · The paper itself

Abstract

Although the roles of initiation factors, RNA binding proteins, and RNA elements in regulating translation are well defined, how the ribosome functionally diversifies remains poorly understood. In their human hosts, poxviruses phosphorylate serine 278 (S

Indexed as

HumansModels, MolecularNeoplasm ProteinsPeptide Chain Initiation, TranslationalProtein BiosynthesisReceptors for Activated C KinaseRibosomesRibosome Subunits, Small, EukaryoticNeoplasm ProteinsRACK1 protein, humanReceptors for Activated C Kinasealternative initiationcryo-EMIRESmRNA specificationpost-translational modificationprotein synthesisribosomeselective translationstructure

Identifiers

PMID34496247
PMCPMC8451006
OpenAlexW3196749746

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.