ArticleCell reports2021
Clostridioides difficile infection induces a rapid influx of bile acids into the gut during colonization of the host.
Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 30 citations in OpenAlex.
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- Long-term endurance exercise influences exercise capacity in mice through modulation of the intestinal microbiota by fecal microbiota transplantation.Frontiers in microbiology · 2026Article
- Matrix-Assisted Laser Desorption/Ionization Imaging Mass Spectrometry.Nature reviews. Methods primers · 2026Article
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- The state of play of rodent models for the study ofJournal of medical microbiology · 2024Review
- Frontiers in Mass Spectrometry-Based Spatial Metabolomics: Current Applications and Challenges in the Context of Biomedical Research.Trends in analytical chemistry : TRAC · 2024Article
- High-Fat Diet-Induced Decreased Circulating Bile Acids Contribute to Obesity Associated with Gut Microbiota in Mice.Foods (Basel, Switzerland) · 2024Article
- Gut Microbiota-Gut Metabolites andMetabolites · 2024Review
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- Sensing and regulation of reactive sulfur species (RSS) in bacteria.Current opinion in chemical biology · 2023Review
- Increased intracellular persulfide levels attenuate HlyU-mediated hemolysin transcriptional activation inbioRxiv : the preprint server for biology · 2023Article
- Clostridioides difficile bile salt hydrolase activity has substrate specificity and affects biofilm formation.NPJ biofilms and microbiomes · 2022Article
- Multimodal Imaging Mass Spectrometry of Murine Gastrointestinal Tract with Retained Luminal Content.Journal of the American Society for Mass Spectrometry · 2022Article
- Total glycosides contribute to the anti-diarrheal effects of Qiwei Baizhu PowderFrontiers in cellular and infection microbiology · 2022Article
- Gut associated metabolites and their roles inGut microbesArticle
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Authors and funding
9 authors at 2 institutions in 1 country.
Funding
Abstract
Clostridioides difficile is the leading cause of nosocomial intestinal infections in the United States. Ingested C. difficile spores encounter host bile acids and other cues that are necessary for germinating into toxin-producing vegetative cells. While gut microbiota disruption (often by antibiotics) is a prerequisite for C. difficile infection (CDI), the mechanisms C. difficile employs for colonization remain unclear. Here, we pioneered the application of imaging mass spectrometry to study how enteric infection changes gut metabolites. We find that CDI induces an influx of bile acids into the gut within 24 h of the host ingesting spores. In response, the host reduces bile acid biosynthesis gene expression. These bile acids drive C. difficile outgrowth, as mice receiving the bile acid sequestrant cholestyramine display delayed colonization and reduced germination. Our findings indicate that C. difficile may facilitate germination upon infection and suggest that altering flux through bile acid pathways can modulate C. difficile outgrowth in CDI-prone patients.
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