Evidence map›Paper›PMID 34496232›Full record

ArticleCell reports2021

SCN2A contributes to oligodendroglia excitability and development in the mammalian brain.

Elizabeth Gould, Jun Hee Kim

Open access · goldAbstract read
In one paragraph

Article in Cell reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.

0numbers the graph read from it
0cells of the map it votes in
22citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

22 citing papers in PubMed, 28 citations in OpenAlex.

  1. Article
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  8. Microglial activation is inhibited by selective anti-seizure medications.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Article
  9. Article
  10. Review
  11. DecodingJournal of clinical medicine · 2025
    Review
  12. Review
  13. Long-Term Excessive Alcohol Consumption Enhances Myelination in the Mouse Nucleus Accumbens.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  14. Physiology of Oligodendroglia.Advances in neurobiology · 2025
    Review
  15. DecipheringArXiv · 2024
    Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Elizabeth GouldDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center, San Antonio, TX 78229, USA.
Jun Hee KimDepartment of Cellular and Integrative Physiology, University of Texas Health Science Center, San Antonio, TX 78229, USA. Electronic address: kimjh@uthscsa.edu.
The University of Texas Health Science Center at San Antonio · US

Funding

PATHOBIOLOGY OF OCCLUSIVE VASCULAR DISEASET32HL007446 · NHLBI · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI Jean Chrisostome Bopassa · 1985 to 2026
$8.9M
Role of SCN2A in Myelination and Neural Circuit Development in Autism Spectrum DisorderR01DC019371 · NIDCD · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KIM, JUN HEE · 2021 to 2025
$2.6M
Genetic profiles and physiological heterogeneity of oligodendrocytesR21NS116573 · NINDS · UNIVERSITY OF TEXAS HLTH SCIENCE CENTER · PI KIM, JUN HEE · 2020 to 2020
$425k
NHLBI NIH HHS T32 HL007446NIDCD NIH HHS R01 DC019371NINDS NIH HHS R21 NS116573
6 · The paper itself

Abstract

Spiking immature oligodendrocytes (OLs), referred to as spiking OLs, express voltage-activated Na

Indexed as

AnimalsBrainCell DifferentiationCell LineageMammalsMiceMyelin SheathOligodendrocyte Precursor CellsOligodendrogliaStem CellsdevelopmentoligodendrocyteSCN2Asingle-cell transcriptomicssodium channel

Identifiers

PMID34496232
PMCPMC8486143
OpenAlexW3197611578

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.