ArticleCell metabolism2021
Deoxyhypusine synthase promotes a pro-inflammatory macrophage phenotype.
Open access · greenAbstract read
In one paragraph
Article in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 37 papers.
0numbers the graph read from it
0cells of the map it votes in
37citing papers in PubMed
3.3field-weighted citation impact, top 6% of its field
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
37 citing papers in PubMed, 59 citations in OpenAlex.
- Regulation of Inducible Nitric Oxide Synthase (NOS2) Expression in Healthy and Inflamed Bowel: A Narrative Review.International journal of molecular sciences · 2026Review
- Blood DNA methylation of EIF5A and TGIF1 is associated with adipose tissue health and metabolic outcomes in obesity: a multi-cohort study.Clinical epigenetics · 2026Article
- A gene therapy strategy for Deoxyhypusine Synthase (DHPS) syndrome.Research square · 2026Article
- Translating the blueprint of cell fate: eIF5A-mediated translation regulates cellular identity in the pancreas.Molecular metabolism · 2026Article
- Development and validation of an immune-related diagnostic signature for breast cancer bone metastasis.Scientific reports · 2026Article
- Article
- Using animal models to decipher the role of polyamines in the pancreas and β Cell.Amino acids · 2026Review
- HLA-DPA1 as a diagnostic biomarker differentiating early- and late-onset preeclampsia.Scientific reports · 2026Article
- Epithelial hypusination regulates Helicobacter pylori-induced gastric inflammation.Amino acids · 2026Article
- A noncanonical polyamine from bacteria antagonizes host mitochondrial function.Nature communications · 2025Article
- Epithelial Hypusination Regulates Helicobacter pylori-induced Gastric Inflammation.Research square · 2025Article
- Mesenchymal stem cell extracellular vesicles ameliorate radiation-caused dry mouth via modulating immune balance and cell metabolism.Stem cell research & therapy · 2025Article
- Polyamine acetylation mediates crosstalk between cancer cells and myeloid cells to promote mesenchymal/plurimetabolic states in glioblastoma.Neuro-oncology · 2025Article
- The integrated stress response promotes macrophage inflammation and migration in autoimmune diabetes.Cell communication and signaling : CCS · 2025Article
- Hippo-YAP/TAZ-ROS signaling axis regulates metaflammation induced by SelenoM deficiency in high-fat diet-derived obesity.Journal of advanced research · 2025Article
- Hypusinated and unhypusinated isoforms of the translation factor eIF5A exert distinct effects in models of pancreas development and function.The Journal of biological chemistry · 2025Article
- Emerging biomedical technologies for scarless wound healing.Bioactive materials · 2024Review
- Deoxyhypusine synthase deficiency syndrome zebrafish model: aberrant morphology, epileptiform activity, and reduced arborization of inhibitory interneurons.Molecular brain · 2024Article
- The Many Faces of Hypusinated eIF5A: Cell Context-Specific Effects of the Hypusine Circuit and Implications for Human Health.International journal of molecular sciences · 2024Review
- Analysis of the effect of hypusination in myeloid cells on colitis and colitis-associated cancer.Heliyon · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
15 authors at 5 institutions in 1 country.
Emily Anderson-BaucumCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Annie R PiñerosCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Abhishek KulkarniDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Bobbie-Jo Webb-RobertsonBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Bernhard MaierCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Ryan M AndersonDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Wenting WuCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA.
Sarah A TerseyDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Teresa L MastracciDepartment of Biology, Indiana University-Purdue University Indianapolis, Indianapolis, IN 46202, USA.
Isabel CasimiroDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA.
Donalyn ScheunerIndiana Biosciences Research Institute, Indianapolis, IN 46202, USA.
Thomas O MetzBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Ernesto S NakayasuBiological Sciences Division, Pacific Northwest National Laboratory, Richland, WA 99352, USA.
Carmella Evans-MolinaCenter for Diabetes and Metabolic Diseases, Indiana University School of Medicine, Indianapolis, IN 46202, USA; Roudebush VA Medical Center, Indianapolis, IN 46202, USA. Electronic address: cevansmo@iu.edu.
Raghavendra G MirmiraDepartment of Medicine, The University of Chicago, Chicago, IL 60637, USA. Electronic address: mirmira@uchicago.edu.
University of Chicago · USIndiana University School of MedicinePacific Northwest National Laboratory · USIndiana University – Purdue University Indianapolis · USIndiana Biosciences Research Institute · US
Funding
Pilot and Feasibility ProgramP30DK020595 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2013 to 2026
$20.9MTranslation CoreP30DK097512 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI Carmella Evans-Molina · 2015 to 2026
$17.4MTranscriptional Mechanisms Governing Beta Cell DifferentiationR01DK060581 · NIDDK · UNIVERSITY OF VIRGINIA CHARLOTTESVILLE · PI Raghavendra G Mirmira · 2002 to 2026
$8.5MThe Integrated Stress Response in Human Islets During Early T1DU01DK127786 · NIDDK · UNIVERSITY OF CHICAGO · PI EVANS-MOLINA, CARMELLA, MIRMIRA, RAGHAVENDRA G · 2020 to 2025
$7.1MRESEARCH TRAINING PROGRAM IN DIABETES AND OBESITYT32DK064466 · NIDDK · INDIANA UNIV-PURDUE UNIV AT INDIANAPOLIS · PI Carmella Evans-Molina, RONALD C WEK · 2003 to 2026
$5.2MRole of Polyamines and Hypusine in Nutrient-Induced Beta-Cell Growth and ReplicationR01DK124906 · NIDDK · UNIVERSITY OF CHICAGO · PI Raghavendra G Mirmira · 2020 to 2026
$4.0MMechanisms of Beta Cell Function in Health and DiseaseR01DK093954 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA · 2011 to 2019
$3.5MExocrine-Endocrine Crosstalk and Determinants of Beta Cell GrowthR01DK121987 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI MASTRACCI, TERESA LOUISE · 2020 to 2024
$2.0Mβ cell miRNAs Function as Molecular Hubs of Type 1 Diabetes PathogenesisR01DK127308 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI EVANS-MOLINA, CARMELLA · 2021 to 2024
$1.7MThe Role of Macrophage Deoxyhypusine Synthase in the Progression of Obesity-Associated Adipose Tissue InflammationF32DK104501 · NIDDK · INDIANA UNIVERSITY INDIANAPOLIS · PI ANDERSON-BAUCUM, EMILY · 2015 to 2015
$52kBLRD VA I01 BX001733NIDDK NIH HHS F32 DK104501NIDDK NIH HHS P30 DK020595NIDDK NIH HHS P30 DK097512NIDDK NIH HHS R01 DK060581NIDDK NIH HHS R01 DK093954NIDDK NIH HHS R01 DK121987NIDDK NIH HHS R01 DK124906NIDDK NIH HHS R01 DK127308NIDDK NIH HHS T32 DK064466NIDDK NIH HHS U01 DK127786
Abstract
The metabolic inflammation (meta-inflammation) of obesity is characterized by proinflammatory macrophage infiltration into adipose tissue. Catalysis by deoxyhypusine synthase (DHPS) modifies the translation factor eIF5A to generate a hypusine (Hyp) residue. Hypusinated eIF5A (eIF5A
Indexed as
Oxidoreductases Acting on CH-NH Group DonorsAdipose TissueAnimalsInflammationMacrophagesMicePhenotypedeoxyhypusine synthaseOxidoreductases Acting on CH-NH Group DonorsdiabeteshypusineinflammationmacrophagemRNA translationobesitypolyaminesproteomicstranscriptomics
Identifiers
What OpenQuestion holds
Textmetadata
LicenceTDM
Read underepoch 390
Registered trials
None linked
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.