Evidence map›Paper›PMID 34496230›Full record

ReviewCell metabolism2021

Exosomes as mediators of intercellular crosstalk in metabolism.

Roi Isaac, Felipe Castellani Gomes Reis, Wei Ying, Jerrold M Olefsky

Open access · bronzeAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Cell metabolism, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 461 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
461citing papers in PubMed, 4 pooled it
41.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

461 citing papers in PubMed, 4 syntheses or guidelines pooled it, 787 citations in OpenAlex.

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401 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Roi IsaacDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Felipe Castellani Gomes ReisDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Wei YingDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA.
Jerrold M OlefskyDivision of Endocrinology & Metabolism, Department of Medicine, University of California, San Diego, San Diego, CA, USA. Electronic address: jolefsky@health.ucsd.edu.
University of California, San Diego · US

Funding

Transgenic & Knock-out MouseP30DK063491 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI Andrea L Hevener · 2003 to 2026
$40.4M
Mechanisms by which hepatocyte extracellular miRNAs mediate peripheral insulin sensitivityR01DK125560 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YING, WEI · 2021 to 2025
$2.0M
Effects of Fractalkine on Beta Cell FunctionR01DK101395 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI OLEFSKY, JERROLD MICHAEL · 2014 to 2017
$1.6M
Adipose tissue macrophages secrete exosome-miRs as paracrine/endocrine molecules to directly modulate insulin target cell function in response to obesityR00DK115998 · NIDDK · UNIVERSITY OF CALIFORNIA, SAN DIEGO · PI YING, WEI · 2020 to 2022
$739k
NIDDK NIH HHS P30 DK063491NIDDK NIH HHS R00 DK115998NIDDK NIH HHS R01 DK101395NIDDK NIH HHS R01 DK125560
6 · The paper itself

Abstract

Exosomes are nanoparticles secreted by all cell types and are a large component of the broader class of nanoparticles termed extracellular vesicles (EVs). Once secreted, exosomes gain access to the interstitial space and ultimately the circulation, where they exert local paracrine or distal systemic effects. Because of this, exosomes are important components of an intercellular and intraorgan communication system capable of carrying biologic signals from one cell type or tissue to another. The exosomal cargo consists of proteins, lipids, miRNAs, and other RNA species, and many of the biologic effects of exosomes have been attributed to miRNAs. Exosomal miRNAs have also been used as disease biomarkers. The field of exosome biology and metabolism is rapidly expanding, with new discoveries and reports appearing on a regular basis, and it is possible that potential therapeutic approaches for the use of exosomes or miRNAs in metabolic diseases will be initiated in the near future.

Indexed as

ExosomesExtracellular VesiclesMetabolic DiseasesMicroRNAsCell CommunicationHumansMicroRNAs

Identifiers

PMID34496230
PMCPMC8428804
OpenAlexW3198011172

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.