ArticleJournal of thrombosis and haemostasis : JTH2021
Assessing the clinical probability of pulmonary embolism during pregnancy: The Pregnancy-Adapted Geneva (PAG) score.
Article in Journal of thrombosis and haemostasis : JTH, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.
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16 citing papers in PubMed, 36 citations in OpenAlex.
- Postoperative venous thromboembolism following cesarean delivery: prevalence, pathophysiology, diagnosis, treatment, and prevention.American journal of obstetrics and gynecology · 2026Review
- Antenatal Pulmonary Embolism Diagnostics in Pregnant Patients with SARS-CoV-2 Infection in Community Hospitals.TH open : companion journal to thrombosis and haemostasis · 2026Article
- Assessment of clinical probability scores for pulmonary embolism diagnosis during pregnancy and postpartum in women with a history of venous thromboembolism: a Highlow ancillary study.Research and practice in thrombosis and haemostasis · 2026Article
- Strategies to Reduce Advanced Imaging in Antenatal Pulmonary Embolism Diagnostics.JAMA network open · 2025Article
- Diagnosing Pulmonary Embolism During Pregnancy.Chest · 2025Review
- Prevalence and Clinical Features of Pulmonary Embolism in Pregnancy and Puerperium in the Post-COVID-19 Era.Maternal and child health journal · 2025Article
- Article
- Pregnancy-Related Cardiovascular Diseases: A Radiological Overview.Journal of cardiovascular development and disease · 2025Review
- Preemptive anticoagulation during antenatal pulmonary embolism diagnostics in a community setting: retrospective cohort study.Research and practice in thrombosis and haemostasis · 2025Article
- Pregnancy-Related Thromboembolism-Current Challenges at the Emergency Department.Journal of personalized medicine · 2024Review
- Pulmonary Embolism in Pregnancy: A Review for Clinical Practitioners.Journal of clinical medicine · 2024Review
- Venous thromboembolism in pregnancy and postpartum: an illustrated review.Research and practice in thrombosis and haemostasis · 2024Article
- Prevention, diagnosis, and management of PE and DVT in pregnant women.Hematology. American Society of Hematology. Education Program · 2023Review
- Diagnosis of Pulmonary Embolism during Pregnancy.Diagnostics (Basel, Switzerland) · 2022Review
- Diagnostic Management of Pregnant Women With Suspected Pulmonary Embolism.Frontiers in cardiovascular medicine · 2022Review
- Assessing the clinical probability of pulmonary embolism during pregnancy: The Pregnancy-Adapted Geneva (PAG) score.Journal of thrombosis and haemostasis : JTH · 2021Article
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Authors and funding
13 authors at 10 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundThe diagnosis of pulmonary embolism (PE) in pregnant women represents an ongoing challenge. As in the general population, the first step in pregnant women with suspected PE consists of assessing clinical pre-test probability (PTP). However, no dedicated clinical decision rule has been developed in this population.
objectiveTo propose a new version of the Geneva score adapted to pregnant women with suspected PE.
methodsData from a multicenter, prospective management outcome study including 395 women with suspected PE, in whom PTP was assessed using the Geneva score, were used. We first removed items which were present in none of the patients (cancer, age >65 years). Receiver operating characteristic (ROC) curve analysis was then performed for quantitative variables and the optimal threshold defined. The obtained Pregnancy-Adapted Geneva Score (PAG Score) comprised seven items, including an age 40 years or older and a heart rate >110 beats per minute.
resultsThe PAG Score showed a high discriminative power to identify patients with a low, intermediate, or high PTP, associated with increasing prevalence of PE, 2.3%, 11.6%, and 61.5%, respectively. The ROC curves showed an area under the curve of 0.795 for the PAG Score compared to 0.684 for the Geneva score.
conclusionIn pregnant women with suspected PE, the PAG Score shows a high discriminative power to identify patients at low, intermediate, or high PTP. It has the strength of being a fully objective decision rule, is clinically relevant, easy to compute, and should now be tested in a prospective outcome study.
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