ArticlePLoS neglected tropical diseases2021
Leptospira interrogans biofilm formation in Rattus norvegicus (Norway rats) natural reservoirs.
Article in PLoS neglected tropical diseases, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 34 citations in OpenAlex.
- Identification ofMicroorganisms · 2026Article
- Antimicrobial and antibiofilm activity of selected flavonoids against pathogenic Leptospira species.Archives of microbiology · 2026Article
- Genetic Diversity ofPathogens (Basel, Switzerland) · 2026Article
- Protocols for Standard and Advanced Visualization and Quantification of Leptospira Biofilms.Methods in molecular biology (Clifton, N.J.) · 2026Article
- Exploring the impact of quercetin on the growth and biofilm formation of Leptospira interrogans.Folia microbiologica · 2025Article
- Article
- Host population dynamics influence Leptospira spp. transmission patterns among Rattus norvegicus in Boston, Massachusetts, US.PLoS neglected tropical diseases · 2025Article
- Review
- The Challenge of Bacterial Strain Identification:Tropical medicine and infectious disease · 2024Article
- Ketone body oxidation and susceptibility to ethyl acetoacetate in a novel hemolytic multidrug-resistant strain Leptospira interrogans KeTo originated from sewage water.Scientific reports · 2024Article
- Leptospira interrogans biofilm transcriptome highlights adaption to starvation and general stress while maintaining virulence.NPJ biofilms and microbiomes · 2024Article
- Comparative genomics ofFrontiers in microbiology · 2024Article
- Landscape, Socioeconomic, and Meteorological Risk Factors for Canine Leptospirosis in Urban Sydney (2017-2023): A Spatial and Temporal Study.Veterinary sciences · 2023Article
- Pathological and molecular study of kidneys in apparently healthy cattle and sheep with special reference toVeterinary world · 2023Article
- Environmental Biofilms from an Urban Community in Salvador, Brazil, Shelter Previously Uncharacterized Saprophytic Leptospira.Microbial ecology · 2023Article
- Impact of Extracellular DNA on Architectural Parameters ofIndian journal of microbiology · 2023Article
- Co-Infection byAnimals : an open access journal from MDPI · 2023Article
- Increased Prevalence of Symptomatic Human Intestinal Spirochetosis in MSM with High-Risk Sexual Behavior in a Cohort of 165 Individuals.Tropical medicine and infectious disease · 2023Article
- Genomic insights into the c-di-GMP signaling and biofilm development in the saprophytic spirochete Leptospira biflexa.Archives of microbiology · 2023Article
- Biofilm formationHeliyon · 2023Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
Rattus norvegicus (Norway rat) is the main reservoir host of pathogenic Leptospira, the causative agent of leptospirosis, in urban environments. Pathogenic Leptospira forms biofilms in the environment, possibly contributing for bacterial survival and maintenance. Nonetheless, biofilms have not yet been studied in natural animal reservoirs presenting leptospiral renal carriage. Here, we described biofilm formation by pathogenic Leptospira inside the renal tubules of R. norvegicus naturally infected and captured in an urban slum endemic for leptospirosis. From the 65 rats carrying Leptospira in their kidneys, 24 (37%) presented biofilms inside the renal tubules. The intensity of leptospiral colonization in the renal tubules (OR: 1.00; 95% CI 1.05-1.1) and the type of occlusion pattern of the colonized renal tubules (OR: 3.46; 95% CI 1.20-9.98) were independently associated with the presence of Leptospira biofilm. Our data showed that Leptospira interrogans produce biofilms during renal chronic colonization in rat reservoirs, suggesting a possible role for leptospiral biofilms in the pathogenesis of leptospirosis and bacterial carriage in host reservoirs.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.