Evidence map›Paper›PMID 34495695›Full record

ArticleJournal of virology2021

Ultradeep HIV-1 Proviral Envelope Sequencing Reveals Complex Population Structure within and between Brain and Splenic Tissues.

Rebecca Rose, Maria Paz Gonzalez-Perez, David J Nolan, Sissy Cross, Susanna L Lamers, Katherine Luzuriaga

Abstract read
In one paragraph

Article in Journal of virology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Rebecca Rose *BioInfoExperts, LLC, Thibodaux, Louisiana, USA.ORCID 0000-0002-5059-9176
Maria Paz Gonzalez-Perez *Program in Molecular Medicine, T.H. Chan School of Medicine at UMass Medical School, Worcester, Massachusetts, USA.
David J NolanBioInfoExperts, LLC, Thibodaux, Louisiana, USA.
Sissy CrossBioInfoExperts, LLC, Thibodaux, Louisiana, USA.
Susanna L LamersBioInfoExperts, LLC, Thibodaux, Louisiana, USA.
Katherine LuzuriagaProgram in Molecular Medicine, T.H. Chan School of Medicine at UMass Medical School, Worcester, Massachusetts, USA.ORCID 0000-0002-5561-1787

Funding

University of Massachusetts Center for Clinical Science and Translational SupplementUL1TR001453 · NCATS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2015 to 2024
$39.0M
Measurement and characterization of CNS and immune tissue myeloid HIV-1 reservoirsR01NS107022 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2018 to 2022
$3.3M
HIV-1 Env conformation and tropism in brain colonization and neuroAIDSR01NS095749 · NINDS · UNIV OF MASSACHUSETTS MED SCH WORCESTER · PI LUZURIAGA, KATHERINE F · 2016 to 2018
$1.3M
HHS | National Institutes of Health (NIH) R01NS107022NCATS NIH HHS UL1 TR001453NINDS NIH HHS R01 NS095749NINDS NIH HHS R01 NS107022
6 · The paper itself

Abstract

Understanding tissue-based HIV-1 proviral population structure is important for improving treatment strategies for individuals with HIV-associated neurological disorders (HAND). Previous analyses have revealed HIV-1 envelope (

Indexed as

BrainGenes, envGenetic VariationHigh-Throughput Nucleotide SequencingHIV-1HIV InfectionsHumansPhylogenyProvirusesSequence Analysis, DNASpleencompartmentalizationphylogeneticsreservoir

Identifiers

PMID34495695
PMCPMC8577351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.